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Metastatic hepatocellular carcinoma in the maxilla and mandible, an extremely rare presentation.

Misra SR, Shankar YU, Rastogi V, Maragathavalli G - Contemp Clin Dent (2015)

Bottom Line: Hepatocellular carcinoma (HCC) is a common primary liver malignancy that frequently metastasizes during the course of the disease, but < 1% of cases show oral involvement.Such secondary neoplasms do not have any pathognomonic clinical or radiologic findings, and therefore they pose a diagnostic challenge.A rare case of HCC metastasizing to both the maxilla and mandible is presented, in which the patient succumbed to the disease as a result of the delay in diagnosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral Medicine and Radiology, Institute of Dental Sciences, Bhubaneswar, Odisha, India.

ABSTRACT
Malignancy is characterized by anaplasia, invasiveness, and metastasis. Primary oral squamous cell carcinoma is the most prevalent oral malignancy, but secondary malignancy from distant sites have also been reported. Hepatocellular carcinoma (HCC) is a common primary liver malignancy that frequently metastasizes during the course of the disease, but < 1% of cases show oral involvement. Such secondary neoplasms do not have any pathognomonic clinical or radiologic findings, and therefore they pose a diagnostic challenge. Hence, in the differential diagnosis of malignant tumors of the oral cavity, it is essential to consider the occurrence of both primary as well as metastatic tumors despite the low incidence of the latter. A rare case of HCC metastasizing to both the maxilla and mandible is presented, in which the patient succumbed to the disease as a result of the delay in diagnosis.

No MeSH data available.


Related in: MedlinePlus

Intra-oral picture showing a restricted mouth opening with an ulcero-proliferative growth in the left mandibular alveolus
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Figure 2: Intra-oral picture showing a restricted mouth opening with an ulcero-proliferative growth in the left mandibular alveolus

Mentions: On clinical examination, a diffuse swelling was seen in the left side of the body of the mandible, ovoid in shape and another diffuse swelling present in the right side of the face. Depressions were seen in the superior part of the swelling in the zygomatic region. On palpation, both the swellings were firm with mild tenderness on palpation. Mouth opening was limited to 20 mm. Intra-oral examination revealed a localized growth present on gingiva and alveolar mucosa extending both buccally and lingually from 33 to 37 region. The growth was irregular in shape; surface was irregular covered by slough. Margins were everted with the obliteration of buccal sulcus, and the growth was firm in consistency, fixed to the underlying bone [Figure 2]. Another swelling was seen in the right buccal mucosa that was spherical in shape, slightly ulcerated in the centre, firm in consistency and nontender on palpation.


Metastatic hepatocellular carcinoma in the maxilla and mandible, an extremely rare presentation.

Misra SR, Shankar YU, Rastogi V, Maragathavalli G - Contemp Clin Dent (2015)

Intra-oral picture showing a restricted mouth opening with an ulcero-proliferative growth in the left mandibular alveolus
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4374307&req=5

Figure 2: Intra-oral picture showing a restricted mouth opening with an ulcero-proliferative growth in the left mandibular alveolus
Mentions: On clinical examination, a diffuse swelling was seen in the left side of the body of the mandible, ovoid in shape and another diffuse swelling present in the right side of the face. Depressions were seen in the superior part of the swelling in the zygomatic region. On palpation, both the swellings were firm with mild tenderness on palpation. Mouth opening was limited to 20 mm. Intra-oral examination revealed a localized growth present on gingiva and alveolar mucosa extending both buccally and lingually from 33 to 37 region. The growth was irregular in shape; surface was irregular covered by slough. Margins were everted with the obliteration of buccal sulcus, and the growth was firm in consistency, fixed to the underlying bone [Figure 2]. Another swelling was seen in the right buccal mucosa that was spherical in shape, slightly ulcerated in the centre, firm in consistency and nontender on palpation.

Bottom Line: Hepatocellular carcinoma (HCC) is a common primary liver malignancy that frequently metastasizes during the course of the disease, but < 1% of cases show oral involvement.Such secondary neoplasms do not have any pathognomonic clinical or radiologic findings, and therefore they pose a diagnostic challenge.A rare case of HCC metastasizing to both the maxilla and mandible is presented, in which the patient succumbed to the disease as a result of the delay in diagnosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral Medicine and Radiology, Institute of Dental Sciences, Bhubaneswar, Odisha, India.

ABSTRACT
Malignancy is characterized by anaplasia, invasiveness, and metastasis. Primary oral squamous cell carcinoma is the most prevalent oral malignancy, but secondary malignancy from distant sites have also been reported. Hepatocellular carcinoma (HCC) is a common primary liver malignancy that frequently metastasizes during the course of the disease, but < 1% of cases show oral involvement. Such secondary neoplasms do not have any pathognomonic clinical or radiologic findings, and therefore they pose a diagnostic challenge. Hence, in the differential diagnosis of malignant tumors of the oral cavity, it is essential to consider the occurrence of both primary as well as metastatic tumors despite the low incidence of the latter. A rare case of HCC metastasizing to both the maxilla and mandible is presented, in which the patient succumbed to the disease as a result of the delay in diagnosis.

No MeSH data available.


Related in: MedlinePlus