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Current challenges in understanding immune cell functions during septic syndromes.

Franks Z, Carlisle M, Rondina MT - BMC Immunol. (2015)

Bottom Line: Sepsis is a dynamic infectious disease syndrome characterized by dysregulated inflammatory responses.These limited advances are likely due, in part, to multiple factors, including substantial heterogeneity in septic syndromes, significant knowledge gaps in our understanding of how immune cells function in sepsis, and limitations in animal models that accurately recapitulate the human septic milieu.We also provide a framework to guide scientists and clinicians in research and patient care as they strive to better understand dysregulated cell responses during sepsis.

View Article: PubMed Central - PubMed

Affiliation: Program in Molecular Medicine, Salt Lake City, 84112, , Utah, USA. zfranks@u2m2.utah.edu.

ABSTRACT

Background: Sepsis is a dynamic infectious disease syndrome characterized by dysregulated inflammatory responses.

Results: Despite decades of research, improvements in the treatment of sepsis have been modest. These limited advances are likely due, in part, to multiple factors, including substantial heterogeneity in septic syndromes, significant knowledge gaps in our understanding of how immune cells function in sepsis, and limitations in animal models that accurately recapitulate the human septic milieu. The goal of this brief review is to describe current challenges in understanding immune cell functions during sepsis. We also provide a framework to guide scientists and clinicians in research and patient care as they strive to better understand dysregulated cell responses during sepsis.

Conclusions: Additional, well-designed translational studies in sepsis are critical for enhancing our understanding of the role of immune cells in sepsis.

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Brief summary of some of the roles and functions of immune cells during septic syndromes.
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Fig1: Brief summary of some of the roles and functions of immune cells during septic syndromes.

Mentions: Although scientific advances continue, there remain many gaps in our understanding of immune cell functions and how they impact host responses during sepsis. Here, we briefly review some of these cells, their known functions during sepsis, and highlight several current challenges in understanding the role and contribution of these cells to the physiology and pathophysiology of sepsis (FigureĀ 1). For further information on macrophages, monocytes, and natural killer cells, as well as the cellular subsets described briefly below, the reader is referred to several recent articles [13,39-42].Figure 1


Current challenges in understanding immune cell functions during septic syndromes.

Franks Z, Carlisle M, Rondina MT - BMC Immunol. (2015)

Brief summary of some of the roles and functions of immune cells during septic syndromes.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4374283&req=5

Fig1: Brief summary of some of the roles and functions of immune cells during septic syndromes.
Mentions: Although scientific advances continue, there remain many gaps in our understanding of immune cell functions and how they impact host responses during sepsis. Here, we briefly review some of these cells, their known functions during sepsis, and highlight several current challenges in understanding the role and contribution of these cells to the physiology and pathophysiology of sepsis (FigureĀ 1). For further information on macrophages, monocytes, and natural killer cells, as well as the cellular subsets described briefly below, the reader is referred to several recent articles [13,39-42].Figure 1

Bottom Line: Sepsis is a dynamic infectious disease syndrome characterized by dysregulated inflammatory responses.These limited advances are likely due, in part, to multiple factors, including substantial heterogeneity in septic syndromes, significant knowledge gaps in our understanding of how immune cells function in sepsis, and limitations in animal models that accurately recapitulate the human septic milieu.We also provide a framework to guide scientists and clinicians in research and patient care as they strive to better understand dysregulated cell responses during sepsis.

View Article: PubMed Central - PubMed

Affiliation: Program in Molecular Medicine, Salt Lake City, 84112, , Utah, USA. zfranks@u2m2.utah.edu.

ABSTRACT

Background: Sepsis is a dynamic infectious disease syndrome characterized by dysregulated inflammatory responses.

Results: Despite decades of research, improvements in the treatment of sepsis have been modest. These limited advances are likely due, in part, to multiple factors, including substantial heterogeneity in septic syndromes, significant knowledge gaps in our understanding of how immune cells function in sepsis, and limitations in animal models that accurately recapitulate the human septic milieu. The goal of this brief review is to describe current challenges in understanding immune cell functions during sepsis. We also provide a framework to guide scientists and clinicians in research and patient care as they strive to better understand dysregulated cell responses during sepsis.

Conclusions: Additional, well-designed translational studies in sepsis are critical for enhancing our understanding of the role of immune cells in sepsis.

Show MeSH
Related in: MedlinePlus