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Angiosarcoma of penis: Case report of an aggressive penile cancer.

Priyadarshi V, Goel HK, Chakrabarty D, Pal DK - Urol Ann (2015 Apr-Jun)

Bottom Line: Angiosarcoma is a very rare mesenchymal tumor of penis.Though extremely unusual, it should be considered in the differential diagnosis in patients presenting with a penile growth or a localized subcutaneous penile lesions as they are very aggressive and there is a high chance of recurrence.One such case is reported here, which was aggressively treated with total penectomy and the patient did not show any recurrence in 2 years of follow-up.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, IPGMER and SSKM Hospital, Kolkata, West Bengal, India.

ABSTRACT
Angiosarcoma is a very rare mesenchymal tumor of penis. Though extremely unusual, it should be considered in the differential diagnosis in patients presenting with a penile growth or a localized subcutaneous penile lesions as they are very aggressive and there is a high chance of recurrence. One such case is reported here, which was aggressively treated with total penectomy and the patient did not show any recurrence in 2 years of follow-up.

No MeSH data available.


Related in: MedlinePlus

Bivalved specimen showing corporal invasion
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Figure 2: Bivalved specimen showing corporal invasion

Mentions: Fungating tumor was 5 cm × 4 cm × 3.5 cm in the dimension that was involving whole of the glans and was extending into both the cavernosa [Figure 2]. On histopathology, tumor was consisted of sheets and nests of large epithelioid and spindle cells with extensive proliferation of irregular and immature vascular channels lined by flattened endothelial cells with cellular atypia and nuclear pleomorphism, with numerous mitotic figures in between and red blood cells within [Figures 3 and 4]. Immunohistochemistry was positive for CD31, CD34 and vimentin and negative for cytokeratin and smooth-muscle actin (SMA), suggestive of angiosarcoma. Surgical margin as well as and left inguinal lymph node was negative for any extension or metastasis.


Angiosarcoma of penis: Case report of an aggressive penile cancer.

Priyadarshi V, Goel HK, Chakrabarty D, Pal DK - Urol Ann (2015 Apr-Jun)

Bivalved specimen showing corporal invasion
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4374270&req=5

Figure 2: Bivalved specimen showing corporal invasion
Mentions: Fungating tumor was 5 cm × 4 cm × 3.5 cm in the dimension that was involving whole of the glans and was extending into both the cavernosa [Figure 2]. On histopathology, tumor was consisted of sheets and nests of large epithelioid and spindle cells with extensive proliferation of irregular and immature vascular channels lined by flattened endothelial cells with cellular atypia and nuclear pleomorphism, with numerous mitotic figures in between and red blood cells within [Figures 3 and 4]. Immunohistochemistry was positive for CD31, CD34 and vimentin and negative for cytokeratin and smooth-muscle actin (SMA), suggestive of angiosarcoma. Surgical margin as well as and left inguinal lymph node was negative for any extension or metastasis.

Bottom Line: Angiosarcoma is a very rare mesenchymal tumor of penis.Though extremely unusual, it should be considered in the differential diagnosis in patients presenting with a penile growth or a localized subcutaneous penile lesions as they are very aggressive and there is a high chance of recurrence.One such case is reported here, which was aggressively treated with total penectomy and the patient did not show any recurrence in 2 years of follow-up.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, IPGMER and SSKM Hospital, Kolkata, West Bengal, India.

ABSTRACT
Angiosarcoma is a very rare mesenchymal tumor of penis. Though extremely unusual, it should be considered in the differential diagnosis in patients presenting with a penile growth or a localized subcutaneous penile lesions as they are very aggressive and there is a high chance of recurrence. One such case is reported here, which was aggressively treated with total penectomy and the patient did not show any recurrence in 2 years of follow-up.

No MeSH data available.


Related in: MedlinePlus