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Primitive neuroectodermal tumor of the kidney in a young male: Case report and review of literature.

Patnaik N, Mishra K, Saini P, Agarwal N - Urol Ann (2015 Apr-Jun)

Bottom Line: A total of approximately 79 primary renal cases have been reported to date.Primitive neuroectodermal tumors occur preferentially in the soft-tissues of the paravertebral region and chest wall, less frequently in extremities, with a slight male predominance.Primitive neuroectodermal tumor of the kidney needs to be kept in mind as a differential diagnosis in young adults presenting with a large kidney mass.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, University College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi, India.

ABSTRACT
Primitive neuroectodermal tumor of the kidney is a rare tumor. A total of approximately 79 primary renal cases have been reported to date. Primitive neuroectodermal tumors occur preferentially in the soft-tissues of the paravertebral region and chest wall, less frequently in extremities, with a slight male predominance. We report a case of primitive neuroectodermal tumor of the kidney in a 17-year-old male with a pre-operative diagnosis of renal cell carcinoma-stage 4. The patient underwent radical nephrectomy and histopathological examination revealed a highly aggressive tumor of monotonous sheets of round cells with focal areas of rosette formations and high mitotic rate with Ki67 index of 25-30%. Tumor cells were positive for CD 99 confirming the diagnosis of primitive neuroectodermal tumor. Primitive neuroectodermal tumor of the kidney needs to be kept in mind as a differential diagnosis in young adults presenting with a large kidney mass.

No MeSH data available.


Related in: MedlinePlus

Tumor cells positive for CD99
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Figure 6: Tumor cells positive for CD99

Mentions: Microscopically, the tumor was composed of monotonous sheets of round cells divided by fibro vascular septae into lobules along with large areas of necrosis [Figure 3]. There were focal areas of rosette formations [Figure 4]. The individual cells had round to ovoid nucleus with a distinct nuclear membrane, fine powdery chromatin and 1 or 2 small nucleoli with 5-10 mitosis per high power field [Figure 5]. The cytoplasm was ill defined, scanty, and pale staining. Three of the four lymph nodes were involved. Immunohistochemically, the tumor cells were positive for CD99 [Figure 6] weakly positive for NSE, focally positive for WT1 but negative for chromogranin. The tumor had a high proliferation rate with labeling index of 25-30 % on Ki67 immunostaining [Figure 7]. A diagnosis of PNET was made based on the above findings and patient was referred to oncology center for further management.


Primitive neuroectodermal tumor of the kidney in a young male: Case report and review of literature.

Patnaik N, Mishra K, Saini P, Agarwal N - Urol Ann (2015 Apr-Jun)

Tumor cells positive for CD99
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4374266&req=5

Figure 6: Tumor cells positive for CD99
Mentions: Microscopically, the tumor was composed of monotonous sheets of round cells divided by fibro vascular septae into lobules along with large areas of necrosis [Figure 3]. There were focal areas of rosette formations [Figure 4]. The individual cells had round to ovoid nucleus with a distinct nuclear membrane, fine powdery chromatin and 1 or 2 small nucleoli with 5-10 mitosis per high power field [Figure 5]. The cytoplasm was ill defined, scanty, and pale staining. Three of the four lymph nodes were involved. Immunohistochemically, the tumor cells were positive for CD99 [Figure 6] weakly positive for NSE, focally positive for WT1 but negative for chromogranin. The tumor had a high proliferation rate with labeling index of 25-30 % on Ki67 immunostaining [Figure 7]. A diagnosis of PNET was made based on the above findings and patient was referred to oncology center for further management.

Bottom Line: A total of approximately 79 primary renal cases have been reported to date.Primitive neuroectodermal tumors occur preferentially in the soft-tissues of the paravertebral region and chest wall, less frequently in extremities, with a slight male predominance.Primitive neuroectodermal tumor of the kidney needs to be kept in mind as a differential diagnosis in young adults presenting with a large kidney mass.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, University College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi, India.

ABSTRACT
Primitive neuroectodermal tumor of the kidney is a rare tumor. A total of approximately 79 primary renal cases have been reported to date. Primitive neuroectodermal tumors occur preferentially in the soft-tissues of the paravertebral region and chest wall, less frequently in extremities, with a slight male predominance. We report a case of primitive neuroectodermal tumor of the kidney in a 17-year-old male with a pre-operative diagnosis of renal cell carcinoma-stage 4. The patient underwent radical nephrectomy and histopathological examination revealed a highly aggressive tumor of monotonous sheets of round cells with focal areas of rosette formations and high mitotic rate with Ki67 index of 25-30%. Tumor cells were positive for CD 99 confirming the diagnosis of primitive neuroectodermal tumor. Primitive neuroectodermal tumor of the kidney needs to be kept in mind as a differential diagnosis in young adults presenting with a large kidney mass.

No MeSH data available.


Related in: MedlinePlus