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Primitive neuroectodermal tumor of the kidney in a young male: Case report and review of literature.

Patnaik N, Mishra K, Saini P, Agarwal N - Urol Ann (2015 Apr-Jun)

Bottom Line: A total of approximately 79 primary renal cases have been reported to date.Primitive neuroectodermal tumors occur preferentially in the soft-tissues of the paravertebral region and chest wall, less frequently in extremities, with a slight male predominance.Primitive neuroectodermal tumor of the kidney needs to be kept in mind as a differential diagnosis in young adults presenting with a large kidney mass.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, University College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi, India.

ABSTRACT
Primitive neuroectodermal tumor of the kidney is a rare tumor. A total of approximately 79 primary renal cases have been reported to date. Primitive neuroectodermal tumors occur preferentially in the soft-tissues of the paravertebral region and chest wall, less frequently in extremities, with a slight male predominance. We report a case of primitive neuroectodermal tumor of the kidney in a 17-year-old male with a pre-operative diagnosis of renal cell carcinoma-stage 4. The patient underwent radical nephrectomy and histopathological examination revealed a highly aggressive tumor of monotonous sheets of round cells with focal areas of rosette formations and high mitotic rate with Ki67 index of 25-30%. Tumor cells were positive for CD 99 confirming the diagnosis of primitive neuroectodermal tumor. Primitive neuroectodermal tumor of the kidney needs to be kept in mind as a differential diagnosis in young adults presenting with a large kidney mass.

No MeSH data available.


Related in: MedlinePlus

A friable, greyish white, lobulated mass, with multiple foci of hemorrhage and necrosis
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Figure 2: A friable, greyish white, lobulated mass, with multiple foci of hemorrhage and necrosis

Mentions: A 17-year-old male presented with complaints of hematuria and heaviness in left flank since 1 month. Physical examination revealed a soft lump in left hypochondrium. Ultrasound examination of the abdomen showed a mass in the left kidney. CT scan of the abdomen demonstrated a large significantly enhancing left renal upper mid polar mass with necrosis and a possible thrombus in left renal vein [Figure 1]. Left radical nephrectomy was performed. Gross examination revealed a friable, grayish white, lobulated mass (15 × 13 × 7 cm3), with multiple foci of hemorrhage and necrosis [Figure 2]. The renal vein and ureter were free of the tumor. Four lymph nodes were dissected from perihilar region.


Primitive neuroectodermal tumor of the kidney in a young male: Case report and review of literature.

Patnaik N, Mishra K, Saini P, Agarwal N - Urol Ann (2015 Apr-Jun)

A friable, greyish white, lobulated mass, with multiple foci of hemorrhage and necrosis
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4374266&req=5

Figure 2: A friable, greyish white, lobulated mass, with multiple foci of hemorrhage and necrosis
Mentions: A 17-year-old male presented with complaints of hematuria and heaviness in left flank since 1 month. Physical examination revealed a soft lump in left hypochondrium. Ultrasound examination of the abdomen showed a mass in the left kidney. CT scan of the abdomen demonstrated a large significantly enhancing left renal upper mid polar mass with necrosis and a possible thrombus in left renal vein [Figure 1]. Left radical nephrectomy was performed. Gross examination revealed a friable, grayish white, lobulated mass (15 × 13 × 7 cm3), with multiple foci of hemorrhage and necrosis [Figure 2]. The renal vein and ureter were free of the tumor. Four lymph nodes were dissected from perihilar region.

Bottom Line: A total of approximately 79 primary renal cases have been reported to date.Primitive neuroectodermal tumors occur preferentially in the soft-tissues of the paravertebral region and chest wall, less frequently in extremities, with a slight male predominance.Primitive neuroectodermal tumor of the kidney needs to be kept in mind as a differential diagnosis in young adults presenting with a large kidney mass.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, University College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi, India.

ABSTRACT
Primitive neuroectodermal tumor of the kidney is a rare tumor. A total of approximately 79 primary renal cases have been reported to date. Primitive neuroectodermal tumors occur preferentially in the soft-tissues of the paravertebral region and chest wall, less frequently in extremities, with a slight male predominance. We report a case of primitive neuroectodermal tumor of the kidney in a 17-year-old male with a pre-operative diagnosis of renal cell carcinoma-stage 4. The patient underwent radical nephrectomy and histopathological examination revealed a highly aggressive tumor of monotonous sheets of round cells with focal areas of rosette formations and high mitotic rate with Ki67 index of 25-30%. Tumor cells were positive for CD 99 confirming the diagnosis of primitive neuroectodermal tumor. Primitive neuroectodermal tumor of the kidney needs to be kept in mind as a differential diagnosis in young adults presenting with a large kidney mass.

No MeSH data available.


Related in: MedlinePlus