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Factors effective on survival after radical prostatectomy: To what extent is pre-operative biopsy Gleason scoring is confident in predicting the prognosis?

Açıkgöz O, Gazel E, Kasap Y, Yığman M, Güneş ZE, Ölçücüoğlu E - Urol Ann (2015 Apr-Jun)

Bottom Line: The difference in-between has been statically found significant (P < 0.001).Similarly, while a 10% (1/10) survival is seen in the patients in Group 1 with Gleason score 8 and above, 75% (3/4) survival has been observed in the patients in Group 2 and 3 with Gleason score 8 and above.Also in this comparison, the difference in-between has been statically found significant (P = 0.041).

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, Turkey Yüksek İhtisas Training and Research Hospital, Ankara, Turkey.

ABSTRACT
In the present study, the effect of different grades on independent survival from the biochemical relapse was investigated through comparison of the histological grades of the biopsy and prostatectomy materials in patients undergoing radical prostatectomy (RP). A total of 152 patients undergoing RP following biopsy were retrospectively investigated in an attempt to reveal the effect of discordance between needle biopsy Gleason score and RP Gleason score on prostate specific antigen relapse-free survival. Accordingly, while 58.3% (14/24) survival was seen in the patients in Group 1 (high-graded) with Gleason score 7, 93.7% (15/16) survival has been seen in the patients in Group 2 (low-graded) and Group 3 (same Gleason scores) with Gleason score 7. The difference in-between has been statically found significant (P < 0.001). Similarly, while a 10% (1/10) survival is seen in the patients in Group 1 with Gleason score 8 and above, 75% (3/4) survival has been observed in the patients in Group 2 and 3 with Gleason score 8 and above. Also in this comparison, the difference in-between has been statically found significant (P = 0.041). Eventually, different grading, particularly determination of Gleason score higher than the RP specimen biopsy also bring about bad pathologic parameters and shortened survival periods.

No MeSH data available.


Related in: MedlinePlus

Time - dependent cumulative “biochemical recurrence - free survival” probabilities of patients in the study group
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Figure 1: Time - dependent cumulative “biochemical recurrence - free survival” probabilities of patients in the study group

Mentions: PSA reoccurrence has developed within the follow-up period in 36 of 15w2 patients admitted to the study and PSA - free survival rate has been calculated to be 76.31%. Survival/time curve of the patients in the study has been shown in (Kaplan-Meier) Graph 1.


Factors effective on survival after radical prostatectomy: To what extent is pre-operative biopsy Gleason scoring is confident in predicting the prognosis?

Açıkgöz O, Gazel E, Kasap Y, Yığman M, Güneş ZE, Ölçücüoğlu E - Urol Ann (2015 Apr-Jun)

Time - dependent cumulative “biochemical recurrence - free survival” probabilities of patients in the study group
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4374252&req=5

Figure 1: Time - dependent cumulative “biochemical recurrence - free survival” probabilities of patients in the study group
Mentions: PSA reoccurrence has developed within the follow-up period in 36 of 15w2 patients admitted to the study and PSA - free survival rate has been calculated to be 76.31%. Survival/time curve of the patients in the study has been shown in (Kaplan-Meier) Graph 1.

Bottom Line: The difference in-between has been statically found significant (P < 0.001).Similarly, while a 10% (1/10) survival is seen in the patients in Group 1 with Gleason score 8 and above, 75% (3/4) survival has been observed in the patients in Group 2 and 3 with Gleason score 8 and above.Also in this comparison, the difference in-between has been statically found significant (P = 0.041).

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, Turkey Yüksek İhtisas Training and Research Hospital, Ankara, Turkey.

ABSTRACT
In the present study, the effect of different grades on independent survival from the biochemical relapse was investigated through comparison of the histological grades of the biopsy and prostatectomy materials in patients undergoing radical prostatectomy (RP). A total of 152 patients undergoing RP following biopsy were retrospectively investigated in an attempt to reveal the effect of discordance between needle biopsy Gleason score and RP Gleason score on prostate specific antigen relapse-free survival. Accordingly, while 58.3% (14/24) survival was seen in the patients in Group 1 (high-graded) with Gleason score 7, 93.7% (15/16) survival has been seen in the patients in Group 2 (low-graded) and Group 3 (same Gleason scores) with Gleason score 7. The difference in-between has been statically found significant (P < 0.001). Similarly, while a 10% (1/10) survival is seen in the patients in Group 1 with Gleason score 8 and above, 75% (3/4) survival has been observed in the patients in Group 2 and 3 with Gleason score 8 and above. Also in this comparison, the difference in-between has been statically found significant (P = 0.041). Eventually, different grading, particularly determination of Gleason score higher than the RP specimen biopsy also bring about bad pathologic parameters and shortened survival periods.

No MeSH data available.


Related in: MedlinePlus