Limits...
A comparative evaluation of the effect of intravenous dexmedetomidine and clonidine on intraocular pressure after suxamethonium and intubation.

Banga PK, Singh DK, Dadu S, Singh M - Saudi J Anaesth (2015 Apr-Jun)

Bottom Line: Following administration of dexmedetomidine and clonidine IOP decreased in both groups.After laryngoscopy and intubation IOP again increased in all three groups but in dexmedetomidine group it never crossed the baseline whereas in clonidine group it was significantly higher than the baseline.Single i.v. dose of dexmedetomidine premedication (0.5 mcg/kg) blunt the IOP and hemodynamic response to suxamethonium injection and tracheal intubation more effectively than single i.v. dose of clonidine premedication (2 mcg/kg).

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology and Critical Care, Shri Guru Ram Rai Institute of Medical and Health Sciences, Dehradun, Uttarakhand, India.

ABSTRACT

Background: In patients with penetrating eye injury and a full stomach, suxamethonium is still used for rapid sequence induction of anesthesia. But its use is associated with the rise in intraocular pressure (IOP) and this can result in permanent vision loss in these patients. Dexmedetomidine and clonidine are two alpha-2 adrenergic agonist drugs which prevent the rise in IOP. The aim of this study is to compare the efficacy of intravenous (i.v.) dexmedetomidine and clonidine in preventing an increase in IOP after administration of suxamethonium and tracheal intubation.

Materials and methods: Sixty patients undergoing elective nonophthalmic surgery under general anesthesia were included in this clinical study. Patients were randomly assigned into three groups to receive 0.5 mcg/kg dexmedetomidine (Group D), 2 mcg/kg clonidine (Group C) or normal saline (Group S) as premedication i.v. over a period of 10 min before induction. IOP, heart rate, and mean arterial pressure were recorded before and after premedication, after suxamethonium, after intubation and then after 5 min.

Results: Following administration of dexmedetomidine and clonidine IOP decreased in both groups. After suxamethonium IOP increased in all three groups but it never crossed the baseline in Group D and C. After laryngoscopy and intubation IOP again increased in all three groups but in dexmedetomidine group it never crossed the baseline whereas in clonidine group it was significantly higher than the baseline.

Conclusion: Single i.v. dose of dexmedetomidine premedication (0.5 mcg/kg) blunt the IOP and hemodynamic response to suxamethonium injection and tracheal intubation more effectively than single i.v. dose of clonidine premedication (2 mcg/kg).

No MeSH data available.


Related in: MedlinePlus

Changes in mean arterial pressure in Groups D, C and S. Measurements were recorded before premedication (T1), after premedication (T2), 30 s after suxamethonium (T3), after intubation (T4) and 5 min after intubation (T5). *P < 0.001 in comparison with T1, †P < 0.001 versus Group D
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4374224&req=5

Figure 3: Changes in mean arterial pressure in Groups D, C and S. Measurements were recorded before premedication (T1), after premedication (T2), 30 s after suxamethonium (T3), after intubation (T4) and 5 min after intubation (T5). *P < 0.001 in comparison with T1, †P < 0.001 versus Group D

Mentions: After premedication, decrease in HR and MAP was observed in Group D and C while significant increase in HR and MAP from baseline was recorded following intubation in Group C and S (P < 0.001). HR and MAP increased significantly after intubation in Group C and S when compared with Group D (HR and MAP: P < 0.001 for Group C and S) [Figures 2 and 3].


A comparative evaluation of the effect of intravenous dexmedetomidine and clonidine on intraocular pressure after suxamethonium and intubation.

Banga PK, Singh DK, Dadu S, Singh M - Saudi J Anaesth (2015 Apr-Jun)

Changes in mean arterial pressure in Groups D, C and S. Measurements were recorded before premedication (T1), after premedication (T2), 30 s after suxamethonium (T3), after intubation (T4) and 5 min after intubation (T5). *P < 0.001 in comparison with T1, †P < 0.001 versus Group D
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4374224&req=5

Figure 3: Changes in mean arterial pressure in Groups D, C and S. Measurements were recorded before premedication (T1), after premedication (T2), 30 s after suxamethonium (T3), after intubation (T4) and 5 min after intubation (T5). *P < 0.001 in comparison with T1, †P < 0.001 versus Group D
Mentions: After premedication, decrease in HR and MAP was observed in Group D and C while significant increase in HR and MAP from baseline was recorded following intubation in Group C and S (P < 0.001). HR and MAP increased significantly after intubation in Group C and S when compared with Group D (HR and MAP: P < 0.001 for Group C and S) [Figures 2 and 3].

Bottom Line: Following administration of dexmedetomidine and clonidine IOP decreased in both groups.After laryngoscopy and intubation IOP again increased in all three groups but in dexmedetomidine group it never crossed the baseline whereas in clonidine group it was significantly higher than the baseline.Single i.v. dose of dexmedetomidine premedication (0.5 mcg/kg) blunt the IOP and hemodynamic response to suxamethonium injection and tracheal intubation more effectively than single i.v. dose of clonidine premedication (2 mcg/kg).

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology and Critical Care, Shri Guru Ram Rai Institute of Medical and Health Sciences, Dehradun, Uttarakhand, India.

ABSTRACT

Background: In patients with penetrating eye injury and a full stomach, suxamethonium is still used for rapid sequence induction of anesthesia. But its use is associated with the rise in intraocular pressure (IOP) and this can result in permanent vision loss in these patients. Dexmedetomidine and clonidine are two alpha-2 adrenergic agonist drugs which prevent the rise in IOP. The aim of this study is to compare the efficacy of intravenous (i.v.) dexmedetomidine and clonidine in preventing an increase in IOP after administration of suxamethonium and tracheal intubation.

Materials and methods: Sixty patients undergoing elective nonophthalmic surgery under general anesthesia were included in this clinical study. Patients were randomly assigned into three groups to receive 0.5 mcg/kg dexmedetomidine (Group D), 2 mcg/kg clonidine (Group C) or normal saline (Group S) as premedication i.v. over a period of 10 min before induction. IOP, heart rate, and mean arterial pressure were recorded before and after premedication, after suxamethonium, after intubation and then after 5 min.

Results: Following administration of dexmedetomidine and clonidine IOP decreased in both groups. After suxamethonium IOP increased in all three groups but it never crossed the baseline in Group D and C. After laryngoscopy and intubation IOP again increased in all three groups but in dexmedetomidine group it never crossed the baseline whereas in clonidine group it was significantly higher than the baseline.

Conclusion: Single i.v. dose of dexmedetomidine premedication (0.5 mcg/kg) blunt the IOP and hemodynamic response to suxamethonium injection and tracheal intubation more effectively than single i.v. dose of clonidine premedication (2 mcg/kg).

No MeSH data available.


Related in: MedlinePlus