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Dexmedetomidine as an adjuvant to ropivacaine in supraclavicular brachial plexus block.

Kathuria S, Gupta S, Dhawan I - Saudi J Anaesth (2015 Apr-Jun)

Bottom Line: Sensory block and motor block onset was earlier in group D than in group D-IV and group C.The sensory block and motor block duration was also prolonged in group D when compared with group D-IV and group C.The action of dexmedetomidine most probably is local rather than centrally mediated.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesia. Dayanand Medical College and Hospital, Ludhiana, Punjab, India.

ABSTRACT

Context: Dexmedetomidine as an adjuvant to local anesthetics in peripheral nerve blocks has been used in only a few studies.

Aims: We aimed at assessing the effect of dexmedetomidine as an adjuvant to ropivacaine in supraclavicular brachial plexus block.

Settings and design: Random, controlled, and triple blind.

Materials and methods: Sixty American Society of Anesthesiologist grade I and II patients of either sex scheduled for elective upper limb surgery under supraclavicular brachial plexus block were divided into three equal groups in a prospective randomized double-blind controlled manner. For block patients in Group C received 0.5% ropivacaine (30cc), 0.5% ropivacaine with 50 μg dexmedetomidine (30cc) in Group D and 0.5% ropivacaine (30cc) in Group D-IV along with intravenous infusion of 50 μg dexmedetomidine in normal saline.

Statistical analysis used: IBM-SPSS software version 17, Chi-square test, Mann-Whitney U-test.

Results: Demographic profile and surgical characteristics were similar in all the three groups. Sensory block and motor block onset was earlier in group D than in group D-IV and group C. The sensory block and motor block duration was also prolonged in group D when compared with group D-IV and group C. The duration of analgesia was significantly longer in group D and D-IV when compared to group C.

Conclusions: Dexmedetomidine as an adjuvant to 0.5%ropivacaine in ultrasound guided brachial plexus block shortens the sensory as well as motor block onset time, prolongs sensory and motor block duration and also increases the duration of analgesia. The action of dexmedetomidine most probably is local rather than centrally mediated.

No MeSH data available.


Related in: MedlinePlus

Sensory and motor block onset time
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Figure 1: Sensory and motor block onset time

Mentions: In our study, we have found that addition of dexmedetomidine (50 μg) to 30 ml ropivacaine 0.5% in ultrasound-guided supraclavicular brachial plexus block resulted in a quick onset of sensory and motor block [Figure 1], prolonged duration of both sensory and motor block [Figure 2], delayed time to first request for analgesia supplementation, that is, prolonged duration of analgesia, and significantly decreased 24 h analgesic consumption [Figure 3] and a good quality of analgesia when compared with control group (ropivacaine 0.5% alone in block).


Dexmedetomidine as an adjuvant to ropivacaine in supraclavicular brachial plexus block.

Kathuria S, Gupta S, Dhawan I - Saudi J Anaesth (2015 Apr-Jun)

Sensory and motor block onset time
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4374219&req=5

Figure 1: Sensory and motor block onset time
Mentions: In our study, we have found that addition of dexmedetomidine (50 μg) to 30 ml ropivacaine 0.5% in ultrasound-guided supraclavicular brachial plexus block resulted in a quick onset of sensory and motor block [Figure 1], prolonged duration of both sensory and motor block [Figure 2], delayed time to first request for analgesia supplementation, that is, prolonged duration of analgesia, and significantly decreased 24 h analgesic consumption [Figure 3] and a good quality of analgesia when compared with control group (ropivacaine 0.5% alone in block).

Bottom Line: Sensory block and motor block onset was earlier in group D than in group D-IV and group C.The sensory block and motor block duration was also prolonged in group D when compared with group D-IV and group C.The action of dexmedetomidine most probably is local rather than centrally mediated.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesia. Dayanand Medical College and Hospital, Ludhiana, Punjab, India.

ABSTRACT

Context: Dexmedetomidine as an adjuvant to local anesthetics in peripheral nerve blocks has been used in only a few studies.

Aims: We aimed at assessing the effect of dexmedetomidine as an adjuvant to ropivacaine in supraclavicular brachial plexus block.

Settings and design: Random, controlled, and triple blind.

Materials and methods: Sixty American Society of Anesthesiologist grade I and II patients of either sex scheduled for elective upper limb surgery under supraclavicular brachial plexus block were divided into three equal groups in a prospective randomized double-blind controlled manner. For block patients in Group C received 0.5% ropivacaine (30cc), 0.5% ropivacaine with 50 μg dexmedetomidine (30cc) in Group D and 0.5% ropivacaine (30cc) in Group D-IV along with intravenous infusion of 50 μg dexmedetomidine in normal saline.

Statistical analysis used: IBM-SPSS software version 17, Chi-square test, Mann-Whitney U-test.

Results: Demographic profile and surgical characteristics were similar in all the three groups. Sensory block and motor block onset was earlier in group D than in group D-IV and group C. The sensory block and motor block duration was also prolonged in group D when compared with group D-IV and group C. The duration of analgesia was significantly longer in group D and D-IV when compared to group C.

Conclusions: Dexmedetomidine as an adjuvant to 0.5%ropivacaine in ultrasound guided brachial plexus block shortens the sensory as well as motor block onset time, prolongs sensory and motor block duration and also increases the duration of analgesia. The action of dexmedetomidine most probably is local rather than centrally mediated.

No MeSH data available.


Related in: MedlinePlus