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A randomized controlled prospective study comparing a low dose bupivacaine and fentanyl mixture to a conventional dose of hyperbaric bupivacaine for cesarean section.

Venkata HG, Pasupuleti S, Pabba UG, Porika S, Talari G - Saudi J Anaesth (2015 Apr-Jun)

Bottom Line: Any greater dose of local anesthetics can cause hemodynamic instability, maternal morbidity and any lesser dose can produce inadequate block.Chicago), paired t-test was used as applicable.The blood pressure significantly decreased with >25% fall from the baseline in group-C (98.76 ± 8.36) than in group-S (117.32 ± 12.21) with P < 0.001.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology and Critical Care, Gandhi Medical College/Hospital, Secunderabad, Telangana, India.

ABSTRACT

Context: Hormonal and mechanical factors make obstetric patients need strict dose calculations of local anesthetics intrathecally for spinal anesthesia. Any greater dose of local anesthetics can cause hemodynamic instability, maternal morbidity and any lesser dose can produce inadequate block. Hence, we hypothesized in our study that by using low dose of bupivacaine with fentanyl can maintain stable hemodynamics and provide better analgesia.

Aim: The aim was to compare the hemodynamics and duration of analgesia using a low dose (7.5 mg) bupivacaine fentanyl mixture to a conventional dose (10 mg) of hyperbaric bupivacaine for cesarean section.

Settings and design: Double-blinded, randomized, controlled prospective study was conducted at a tertiary academic hospital from 2008 to 2011.

Materials and methods: Fifty singleton parturient, scheduled for elective caesarean section were randomly allocated into two groups. Study group (group-S) received a combination of 25 μg fentanyl and 7.5 mg of hyperbaric bupivacaine, whereas the control group (group-C) received 10 mg of hyperbaric bupivacaine. Maternal hemodynamics, sensory and motor block, duration of analgesia and the Apgar score of the newborn were compared between the groups.

Statistical analysis used: Observational descriptive statistics, statistical package for social sciences (SPSS Inc. Released 2006, SPSS for Windows, Version 15.0. Chicago), paired t-test was used as applicable.

Results: The blood pressure significantly decreased with >25% fall from the baseline in group-C (98.76 ± 8.36) than in group-S (117.32 ± 12.21) with P < 0.001. The duration of effective analgesia was significantly prolonged in the study group than in the control group (P < 0.001).

Conclusion: The combination of low dose bupivacaine and fentanyl in comparison to bupivacaine alone is hemodynamically stable and prolonged duration of analgesia in caesarean section.

No MeSH data available.


Related in: MedlinePlus

Time of onset of sensory block in minutes
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Figure 3: Time of onset of sensory block in minutes

Mentions: The time required for the onset of sensory block till T10 dermatome and the target sensory block of T6 dermatome was significantly faster in group S (3.32 min ± 0.8 min) than in group C (4.42 min ± 0.41 min) with (P < 0.001) [Figure 3]. However, there was no significant difference between both the groups in the quality of surgical anesthesia.


A randomized controlled prospective study comparing a low dose bupivacaine and fentanyl mixture to a conventional dose of hyperbaric bupivacaine for cesarean section.

Venkata HG, Pasupuleti S, Pabba UG, Porika S, Talari G - Saudi J Anaesth (2015 Apr-Jun)

Time of onset of sensory block in minutes
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4374214&req=5

Figure 3: Time of onset of sensory block in minutes
Mentions: The time required for the onset of sensory block till T10 dermatome and the target sensory block of T6 dermatome was significantly faster in group S (3.32 min ± 0.8 min) than in group C (4.42 min ± 0.41 min) with (P < 0.001) [Figure 3]. However, there was no significant difference between both the groups in the quality of surgical anesthesia.

Bottom Line: Any greater dose of local anesthetics can cause hemodynamic instability, maternal morbidity and any lesser dose can produce inadequate block.Chicago), paired t-test was used as applicable.The blood pressure significantly decreased with >25% fall from the baseline in group-C (98.76 ± 8.36) than in group-S (117.32 ± 12.21) with P < 0.001.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology and Critical Care, Gandhi Medical College/Hospital, Secunderabad, Telangana, India.

ABSTRACT

Context: Hormonal and mechanical factors make obstetric patients need strict dose calculations of local anesthetics intrathecally for spinal anesthesia. Any greater dose of local anesthetics can cause hemodynamic instability, maternal morbidity and any lesser dose can produce inadequate block. Hence, we hypothesized in our study that by using low dose of bupivacaine with fentanyl can maintain stable hemodynamics and provide better analgesia.

Aim: The aim was to compare the hemodynamics and duration of analgesia using a low dose (7.5 mg) bupivacaine fentanyl mixture to a conventional dose (10 mg) of hyperbaric bupivacaine for cesarean section.

Settings and design: Double-blinded, randomized, controlled prospective study was conducted at a tertiary academic hospital from 2008 to 2011.

Materials and methods: Fifty singleton parturient, scheduled for elective caesarean section were randomly allocated into two groups. Study group (group-S) received a combination of 25 μg fentanyl and 7.5 mg of hyperbaric bupivacaine, whereas the control group (group-C) received 10 mg of hyperbaric bupivacaine. Maternal hemodynamics, sensory and motor block, duration of analgesia and the Apgar score of the newborn were compared between the groups.

Statistical analysis used: Observational descriptive statistics, statistical package for social sciences (SPSS Inc. Released 2006, SPSS for Windows, Version 15.0. Chicago), paired t-test was used as applicable.

Results: The blood pressure significantly decreased with >25% fall from the baseline in group-C (98.76 ± 8.36) than in group-S (117.32 ± 12.21) with P < 0.001. The duration of effective analgesia was significantly prolonged in the study group than in the control group (P < 0.001).

Conclusion: The combination of low dose bupivacaine and fentanyl in comparison to bupivacaine alone is hemodynamically stable and prolonged duration of analgesia in caesarean section.

No MeSH data available.


Related in: MedlinePlus