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Comparison the effects of paracetamol with sufentanil infusion on postoperative pain control after craniotomy in patients with brain tumor.

Hassani E, Mahoori A, Sane S, Tolumehr A - Adv Biomed Res (2015)

Bottom Line: The effect of sufentanil and paracetamol medicines in pain management, hemodynamic stability, and side effects compared with control group that were receiving morphine (subcutaneous [SC]) in 3 groups of 15 people at time 0, 2, 4, 12 and 24-h were evaluated.There was a significant difference in mean arterial pressure between 3 groups (P < 0.05).There was no significant difference in Glasgow Coma scale and SPO2 between 3 groups (P > 0.05).

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology, Urmia University of Medical Sciences, Urmia, Iran.

ABSTRACT

Background: Patients experience severe pain after craniotomy surgery that leads to discomfort. Our target in this study that performed in interventional method is an evaluation of sufentanil and paracetamol effect on postoperative pain control in patients undergone craniotomy surgery at Urmia Imam Khomeini Hospital.

Materials and methods: Totally, 45 patients between the ages 18 and 65 were studied. The effect of sufentanil and paracetamol medicines in pain management, hemodynamic stability, and side effects compared with control group that were receiving morphine (subcutaneous [SC]) in 3 groups of 15 people at time 0, 2, 4, 12 and 24-h were evaluated. Collected data were included and monitoring blood pressure, O2 Sat, heart rate (HR) and pain, nausea, vomiting and use of morphine.

Results: According to the analysis of results, there was a significant difference between 3 groups on postoperative pain (P < 0.05). In patients that used sufentanil, pain score of visual analog scale (VAS) is lowest and in the paracetamol group the highest VAS score was seen. There was a significant difference in HR between 3 groups (P < 0.05). Maximum average of HR was observed in the paracetamol group. There was a significant difference in mean arterial pressure between 3 groups (P < 0.05). In paracetamol group, there was the highest value (99.3). There was no significant difference in Glasgow Coma scale and SPO2 between 3 groups (P > 0.05).

Conclusion: Sufentanil compared to morphine (which is routinely used for patients pain control after craniotomy surgery) has better pain control, less nausea and vomiting, and better hemodynamic stability. Although paracetamol has the least nausea and vomiting, it has the lowest quality of pain relief.

No MeSH data available.


Related in: MedlinePlus

Mean arterial pressure in three groups
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Figure 2: Mean arterial pressure in three groups

Mentions: Significant difference was observed in three groups (P = 0.003). Highest 24-h average of MAP was seen in the paracetamol group (99.3), and it was lowest in the sufentanil group (94.1). Morphine group showed intermediate MAP (97.6) [Table 1, Figure 2].


Comparison the effects of paracetamol with sufentanil infusion on postoperative pain control after craniotomy in patients with brain tumor.

Hassani E, Mahoori A, Sane S, Tolumehr A - Adv Biomed Res (2015)

Mean arterial pressure in three groups
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4374201&req=5

Figure 2: Mean arterial pressure in three groups
Mentions: Significant difference was observed in three groups (P = 0.003). Highest 24-h average of MAP was seen in the paracetamol group (99.3), and it was lowest in the sufentanil group (94.1). Morphine group showed intermediate MAP (97.6) [Table 1, Figure 2].

Bottom Line: The effect of sufentanil and paracetamol medicines in pain management, hemodynamic stability, and side effects compared with control group that were receiving morphine (subcutaneous [SC]) in 3 groups of 15 people at time 0, 2, 4, 12 and 24-h were evaluated.There was a significant difference in mean arterial pressure between 3 groups (P < 0.05).There was no significant difference in Glasgow Coma scale and SPO2 between 3 groups (P > 0.05).

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology, Urmia University of Medical Sciences, Urmia, Iran.

ABSTRACT

Background: Patients experience severe pain after craniotomy surgery that leads to discomfort. Our target in this study that performed in interventional method is an evaluation of sufentanil and paracetamol effect on postoperative pain control in patients undergone craniotomy surgery at Urmia Imam Khomeini Hospital.

Materials and methods: Totally, 45 patients between the ages 18 and 65 were studied. The effect of sufentanil and paracetamol medicines in pain management, hemodynamic stability, and side effects compared with control group that were receiving morphine (subcutaneous [SC]) in 3 groups of 15 people at time 0, 2, 4, 12 and 24-h were evaluated. Collected data were included and monitoring blood pressure, O2 Sat, heart rate (HR) and pain, nausea, vomiting and use of morphine.

Results: According to the analysis of results, there was a significant difference between 3 groups on postoperative pain (P < 0.05). In patients that used sufentanil, pain score of visual analog scale (VAS) is lowest and in the paracetamol group the highest VAS score was seen. There was a significant difference in HR between 3 groups (P < 0.05). Maximum average of HR was observed in the paracetamol group. There was a significant difference in mean arterial pressure between 3 groups (P < 0.05). In paracetamol group, there was the highest value (99.3). There was no significant difference in Glasgow Coma scale and SPO2 between 3 groups (P > 0.05).

Conclusion: Sufentanil compared to morphine (which is routinely used for patients pain control after craniotomy surgery) has better pain control, less nausea and vomiting, and better hemodynamic stability. Although paracetamol has the least nausea and vomiting, it has the lowest quality of pain relief.

No MeSH data available.


Related in: MedlinePlus