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Malignant tenosynovial giant cell tumor of the leg: a radiologic-pathologic correlation and review of the literature.

Richman DM, Bresler SC, Rosenthal MH, Howard SA - J Clin Imaging Sci (2015)

Bottom Line: Malignant tenosynovial giant cell tumor (TGCT) is a rare clinical entity that can arise as a recurrent lesion or can co-exist with a benign TGCT lesion.Malignant TGCT most commonly arises in the lower extremity and tends to be clinically aggressive, with most patients developing recurrent lesions or dying.Much of the literature describes the histopathologic features and classifies this broad group of tumors, with little description of the imaging characteristics of this disease.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA ; Harvard Medical School, Boston, Massachusetts, USA.

ABSTRACT
Malignant tenosynovial giant cell tumor (TGCT) is a rare clinical entity that can arise as a recurrent lesion or can co-exist with a benign TGCT lesion. Malignant TGCT most commonly arises in the lower extremity and tends to be clinically aggressive, with most patients developing recurrent lesions or dying. Much of the literature describes the histopathologic features and classifies this broad group of tumors, with little description of the imaging characteristics of this disease. We present the multimodality appearance of a case of malignant diffuse-type TGCT that recurred 2 months after resection with subsequent rapid clinical progression.

No MeSH data available.


Related in: MedlinePlus

55-year-old female 7 weeks post-resection of tenosynovial giant cell tumor with complaints of pain and friable tissue growth at the incision site. (a) Coronal T1-weighted post-contrast MRI of the right knee shows a heterogeneous lobulated lesion extending to the mid-calf. The lesion measures 24.4 cm in craniocaudal dimension. Margins of soft tissue components of the lesion are ill-defined and somewhat infiltrative in some areas (arrowhead). (b) Sagittal T2-weighted MR of the right knee shows both cystic (thick arrow) and solid (thin arrow) areas within the heterogeneous lesion.
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Figure 4: 55-year-old female 7 weeks post-resection of tenosynovial giant cell tumor with complaints of pain and friable tissue growth at the incision site. (a) Coronal T1-weighted post-contrast MRI of the right knee shows a heterogeneous lobulated lesion extending to the mid-calf. The lesion measures 24.4 cm in craniocaudal dimension. Margins of soft tissue components of the lesion are ill-defined and somewhat infiltrative in some areas (arrowhead). (b) Sagittal T2-weighted MR of the right knee shows both cystic (thick arrow) and solid (thin arrow) areas within the heterogeneous lesion.

Mentions: MRI done 7 weeks after initial resection showed a heterogeneous lobulated lesion with enhancement of the solid components, centered within the gastrocnemius and extending 7 cm superior to the tibiofemoral joint [Figure 4]. Popliteal vessels and nerves were encased by the tumor. Low-volume lymph nodes in the right inguinal region were unchanged. Given the aggressive appearance of the lesion, the patient underwent a below the knee amputation.


Malignant tenosynovial giant cell tumor of the leg: a radiologic-pathologic correlation and review of the literature.

Richman DM, Bresler SC, Rosenthal MH, Howard SA - J Clin Imaging Sci (2015)

55-year-old female 7 weeks post-resection of tenosynovial giant cell tumor with complaints of pain and friable tissue growth at the incision site. (a) Coronal T1-weighted post-contrast MRI of the right knee shows a heterogeneous lobulated lesion extending to the mid-calf. The lesion measures 24.4 cm in craniocaudal dimension. Margins of soft tissue components of the lesion are ill-defined and somewhat infiltrative in some areas (arrowhead). (b) Sagittal T2-weighted MR of the right knee shows both cystic (thick arrow) and solid (thin arrow) areas within the heterogeneous lesion.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4374198&req=5

Figure 4: 55-year-old female 7 weeks post-resection of tenosynovial giant cell tumor with complaints of pain and friable tissue growth at the incision site. (a) Coronal T1-weighted post-contrast MRI of the right knee shows a heterogeneous lobulated lesion extending to the mid-calf. The lesion measures 24.4 cm in craniocaudal dimension. Margins of soft tissue components of the lesion are ill-defined and somewhat infiltrative in some areas (arrowhead). (b) Sagittal T2-weighted MR of the right knee shows both cystic (thick arrow) and solid (thin arrow) areas within the heterogeneous lesion.
Mentions: MRI done 7 weeks after initial resection showed a heterogeneous lobulated lesion with enhancement of the solid components, centered within the gastrocnemius and extending 7 cm superior to the tibiofemoral joint [Figure 4]. Popliteal vessels and nerves were encased by the tumor. Low-volume lymph nodes in the right inguinal region were unchanged. Given the aggressive appearance of the lesion, the patient underwent a below the knee amputation.

Bottom Line: Malignant tenosynovial giant cell tumor (TGCT) is a rare clinical entity that can arise as a recurrent lesion or can co-exist with a benign TGCT lesion.Malignant TGCT most commonly arises in the lower extremity and tends to be clinically aggressive, with most patients developing recurrent lesions or dying.Much of the literature describes the histopathologic features and classifies this broad group of tumors, with little description of the imaging characteristics of this disease.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA ; Harvard Medical School, Boston, Massachusetts, USA.

ABSTRACT
Malignant tenosynovial giant cell tumor (TGCT) is a rare clinical entity that can arise as a recurrent lesion or can co-exist with a benign TGCT lesion. Malignant TGCT most commonly arises in the lower extremity and tends to be clinically aggressive, with most patients developing recurrent lesions or dying. Much of the literature describes the histopathologic features and classifies this broad group of tumors, with little description of the imaging characteristics of this disease. We present the multimodality appearance of a case of malignant diffuse-type TGCT that recurred 2 months after resection with subsequent rapid clinical progression.

No MeSH data available.


Related in: MedlinePlus