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Unravelling the hidden ancestry of American admixed populations.

Montinaro F, Busby GB, Pascali VL, Myers S, Hellenthal G, Capelli C - Nat Commun (2015)

Bottom Line: The movement of people into the Americas has brought different populations into contact, and contemporary American genomes are the product of a range of complex admixture events.Here we apply a haplotype-based ancestry identification approach to a large set of genome-wide SNP data from a variety of American, European and African populations to determine the contributions of different ancestral populations to the Americas.Our results provide a fine-scale characterization of the source populations, identify a series of novel, previously unreported contributions from Africa and Europe and highlight geohistorical structure in the ancestry of American admixed populations.

View Article: PubMed Central - PubMed

Affiliation: 1] Institute of Legal Medicine, Catholic University, Largo F. Vito 1, Rome 00168, Italy [2] Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK.

ABSTRACT
The movement of people into the Americas has brought different populations into contact, and contemporary American genomes are the product of a range of complex admixture events. Here we apply a haplotype-based ancestry identification approach to a large set of genome-wide SNP data from a variety of American, European and African populations to determine the contributions of different ancestral populations to the Americas. Our results provide a fine-scale characterization of the source populations, identify a series of novel, previously unreported contributions from Africa and Europe and highlight geohistorical structure in the ancestry of American admixed populations.

No MeSH data available.


fineSTRUCTURE clustering of the analysed individuals.Tree of the analysed individuals pooled in 78 clusters as inferred by fineSTRUCTURE. Colours follow macro-area affiliations as in Fig. 1.
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f2: fineSTRUCTURE clustering of the analysed individuals.Tree of the analysed individuals pooled in 78 clusters as inferred by fineSTRUCTURE. Colours follow macro-area affiliations as in Fig. 1.

Mentions: In order to minimize the impact of within-source genetic heterogeneity in the ancestry characterization process, we partitioned the 1,414 individuals from 42 population-label donors into genetically homogeneous clusters using a CHROMOPAINTER and fineSTRUCTURE analysis as described in the Methods section. This identified 78 clusters (Fig. 2, Supplementary Table 2) related by a hierarchical tree, with a broad correlation between clusters and geographic origin, allowing the grouping of clusters in 13 groups within Europe, Africa and East Asia/America (Fig. 2; Supplementary Table 2).


Unravelling the hidden ancestry of American admixed populations.

Montinaro F, Busby GB, Pascali VL, Myers S, Hellenthal G, Capelli C - Nat Commun (2015)

fineSTRUCTURE clustering of the analysed individuals.Tree of the analysed individuals pooled in 78 clusters as inferred by fineSTRUCTURE. Colours follow macro-area affiliations as in Fig. 1.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4374169&req=5

f2: fineSTRUCTURE clustering of the analysed individuals.Tree of the analysed individuals pooled in 78 clusters as inferred by fineSTRUCTURE. Colours follow macro-area affiliations as in Fig. 1.
Mentions: In order to minimize the impact of within-source genetic heterogeneity in the ancestry characterization process, we partitioned the 1,414 individuals from 42 population-label donors into genetically homogeneous clusters using a CHROMOPAINTER and fineSTRUCTURE analysis as described in the Methods section. This identified 78 clusters (Fig. 2, Supplementary Table 2) related by a hierarchical tree, with a broad correlation between clusters and geographic origin, allowing the grouping of clusters in 13 groups within Europe, Africa and East Asia/America (Fig. 2; Supplementary Table 2).

Bottom Line: The movement of people into the Americas has brought different populations into contact, and contemporary American genomes are the product of a range of complex admixture events.Here we apply a haplotype-based ancestry identification approach to a large set of genome-wide SNP data from a variety of American, European and African populations to determine the contributions of different ancestral populations to the Americas.Our results provide a fine-scale characterization of the source populations, identify a series of novel, previously unreported contributions from Africa and Europe and highlight geohistorical structure in the ancestry of American admixed populations.

View Article: PubMed Central - PubMed

Affiliation: 1] Institute of Legal Medicine, Catholic University, Largo F. Vito 1, Rome 00168, Italy [2] Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK.

ABSTRACT
The movement of people into the Americas has brought different populations into contact, and contemporary American genomes are the product of a range of complex admixture events. Here we apply a haplotype-based ancestry identification approach to a large set of genome-wide SNP data from a variety of American, European and African populations to determine the contributions of different ancestral populations to the Americas. Our results provide a fine-scale characterization of the source populations, identify a series of novel, previously unreported contributions from Africa and Europe and highlight geohistorical structure in the ancestry of American admixed populations.

No MeSH data available.