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TopBP1 interacts with BLM to maintain genome stability but is dispensable for preventing BLM degradation.

Blackford AN, Nieminuszczy J, Schwab RA, Galanty Y, Jackson SP, Niedzwiedz W - Mol. Cell (2015)

Bottom Line: Here, we show that the BLM-TopBP1 interaction does not involve Ser338 but instead requires BLM phosphorylation on Ser304.Furthermore, we establish that disrupting this interaction does not markedly affect BLM stability.Taken together, our findings provide molecular insights into a key tumor suppressor and genome stability network.

View Article: PubMed Central - PubMed

Affiliation: The Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK; The Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge CB2 1QN, UK.

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TopBP1 interacts with BLM to maintain genome stability but is dispensable for preventing BLM degradation.

Blackford AN, Nieminuszczy J, Schwab RA, Galanty Y, Jackson SP, Niedzwiedz W - Mol. Cell (2015)

© Copyright Policy - CC BY
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4374139&req=5

Bottom Line: Here, we show that the BLM-TopBP1 interaction does not involve Ser338 but instead requires BLM phosphorylation on Ser304.Furthermore, we establish that disrupting this interaction does not markedly affect BLM stability.Taken together, our findings provide molecular insights into a key tumor suppressor and genome stability network.

View Article: PubMed Central - PubMed

Affiliation: The Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK; The Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge CB2 1QN, UK.

No MeSH data available.


Related in: MedlinePlus