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Editorial: Studying the spectrum of allergic and rhinologic disease.

Soler ZM - Am J Rhinol Allergy (2014 Nov-Dec)

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The American Journal of Allergy and Rhinology is committed to expanding knowledge and publishing the best clinical and basic research within the fields of Rhinology & Allergy... The current issue furthers this mission, presenting novel studies investigating the molecular mechanisms of allergic rhinitis and chronic rhinosinusitis... Furthermore, Tang et al explored serum cytokine levels in patients with allergic rhinitis, finding correlations between IL22 and IL17A expression and clinical disease severity... Also in patients with allergic rhinitis, Ciprandi et al examined outcomes from methacholine bronchial challenge, showing that those with bronchial hyperreactivity had more severe nasal disease and likely represent a discrete phenotype with distinct clinical needs... Choby et al also perform a systematic review on outcomes related to middle turbinate resection, a topic which has remained controversial since the early years of endoscopic sinus surgery... The authors concluded this practice can be appropriate in selected cases... Rereddy et al also examined fine-cut CT scans but looked at pneumatization patterns... They found five anatomic variations which were associated with increased pneumatization and that many were correlated... Additionally, Al-Qudah examined whether the addition of epinephrine improved tolerance and performance of diagnostic sinonasal endoscopy... In this randomized, double-blind, placebo controlled study, the addition of epinephrine did not appear to add additional benefit to lidocaine alone... This data and the recommendations put forth to avoid such claims will be of interest to surgeons and non-surgeons alike who manage patients with rhinologic disease... Lastly, Akdag et al present a study on the effects of prolonged room air fresheners on rat mucosa... They found significant inflammation and evidence of squamous metaplasia which occurred after 3 months of ongoing exposure, suggesting that additional safety studies should be done in human populations... Taken together, the current issue of the American Journal of Allergy and Rhinology covers the spectrum of allergic and rhinologic disease, from novel mechanistic studies to randomized clinical trials of current medical and surgical treatments.

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Zachary M. Soler, M.D., M.Sc.
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Editorial: Studying the spectrum of allergic and rhinologic disease.

Soler ZM - Am J Rhinol Allergy (2014 Nov-Dec)

Zachary M. Soler, M.D., M.Sc.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4374137&req=5

FU1: Zachary M. Soler, M.D., M.Sc.

View Article: PubMed Central - PubMed

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

The American Journal of Allergy and Rhinology is committed to expanding knowledge and publishing the best clinical and basic research within the fields of Rhinology & Allergy... The current issue furthers this mission, presenting novel studies investigating the molecular mechanisms of allergic rhinitis and chronic rhinosinusitis... Furthermore, Tang et al explored serum cytokine levels in patients with allergic rhinitis, finding correlations between IL22 and IL17A expression and clinical disease severity... Also in patients with allergic rhinitis, Ciprandi et al examined outcomes from methacholine bronchial challenge, showing that those with bronchial hyperreactivity had more severe nasal disease and likely represent a discrete phenotype with distinct clinical needs... Choby et al also perform a systematic review on outcomes related to middle turbinate resection, a topic which has remained controversial since the early years of endoscopic sinus surgery... The authors concluded this practice can be appropriate in selected cases... Rereddy et al also examined fine-cut CT scans but looked at pneumatization patterns... They found five anatomic variations which were associated with increased pneumatization and that many were correlated... Additionally, Al-Qudah examined whether the addition of epinephrine improved tolerance and performance of diagnostic sinonasal endoscopy... In this randomized, double-blind, placebo controlled study, the addition of epinephrine did not appear to add additional benefit to lidocaine alone... This data and the recommendations put forth to avoid such claims will be of interest to surgeons and non-surgeons alike who manage patients with rhinologic disease... Lastly, Akdag et al present a study on the effects of prolonged room air fresheners on rat mucosa... They found significant inflammation and evidence of squamous metaplasia which occurred after 3 months of ongoing exposure, suggesting that additional safety studies should be done in human populations... Taken together, the current issue of the American Journal of Allergy and Rhinology covers the spectrum of allergic and rhinologic disease, from novel mechanistic studies to randomized clinical trials of current medical and surgical treatments.

Show MeSH