Limits...
The pathophysiology of sinonasal conditions and novel therapeutic options.

Peters AT - Am J Rhinol Allergy (2014 May-Jun)

View Article: PubMed Central - PubMed

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

The May issue of the American Journal of Rhinology and Allergy includes a high-quality blend of articles investigating the pathophysiology of sinonasal conditions and novel therapeutic options... Quite a few articles in this issue delve into the pathophysiology of chronic rhinosinusitis (CRS)... In this issue, Kupper et al. report lower expression of factors involved in apoptosis; caspases 3, 7, and 9; and p53 protein in NP tissue compared with control tissue... They conclude that reduction in these factors involved in apoptosis may be responsible for the higher proliferation of inflammatory cells in CRSwNPs... They showed p38 MAPK–dependent decrease in MUC5AC expression with chronic cholesterol depletion... This could be a possible therapeutic target to decrease mucus secretion associated with sinonasal disease... All three methods improved symptoms as measured by a visual analog scale at 1 month and 1 year postoperatively and there was no significant difference between the three methods... Su et al. compared the effects of two different surgical approaches for vidian neurectomy on lacrimation and dry eye syndrome... The current issue of the American Journal of Rhinology and Allergy is notable for articles investigating the pathogenesis of allergic rhinitis (AR)... They used the knowledge that recombinant DNA plasmids encoding allergens may activate Th1 and dampen Th2 responses by injecting recombinant plasmid Cyn d 1 in neonatal BAL/c mice... They found heightened Th1 response as shown by production of interferon γ and reduction of Th2 response and specifically lowered specific IgE responses and IL-4 in spleen cells... This may be one of the possible mechanisms for IT's anti-inflammatory action... IT was associated with improvement in symptom scores, decrease in rescue medication use, and decreased nasal eosinophilia... In addition to the pathophysiology of upper airway disease, the journal also has thought-provoking articles on therapeutic options that should be of interest to all those researching and taking care of patients with sinonasal diseases... Once again, the May issue of the American Journal of Rhinology and Allergy contains a diverse array of articles in the field of sinonasal diseases that are important in research and clinical care of patients.

Show MeSH

Related in: MedlinePlus

Anju T. Peters, M.D.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4374136&req=5

FU1: Anju T. Peters, M.D.


The pathophysiology of sinonasal conditions and novel therapeutic options.

Peters AT - Am J Rhinol Allergy (2014 May-Jun)

Anju T. Peters, M.D.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4374136&req=5

FU1: Anju T. Peters, M.D.

View Article: PubMed Central - PubMed

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

The May issue of the American Journal of Rhinology and Allergy includes a high-quality blend of articles investigating the pathophysiology of sinonasal conditions and novel therapeutic options... Quite a few articles in this issue delve into the pathophysiology of chronic rhinosinusitis (CRS)... In this issue, Kupper et al. report lower expression of factors involved in apoptosis; caspases 3, 7, and 9; and p53 protein in NP tissue compared with control tissue... They conclude that reduction in these factors involved in apoptosis may be responsible for the higher proliferation of inflammatory cells in CRSwNPs... They showed p38 MAPK–dependent decrease in MUC5AC expression with chronic cholesterol depletion... This could be a possible therapeutic target to decrease mucus secretion associated with sinonasal disease... All three methods improved symptoms as measured by a visual analog scale at 1 month and 1 year postoperatively and there was no significant difference between the three methods... Su et al. compared the effects of two different surgical approaches for vidian neurectomy on lacrimation and dry eye syndrome... The current issue of the American Journal of Rhinology and Allergy is notable for articles investigating the pathogenesis of allergic rhinitis (AR)... They used the knowledge that recombinant DNA plasmids encoding allergens may activate Th1 and dampen Th2 responses by injecting recombinant plasmid Cyn d 1 in neonatal BAL/c mice... They found heightened Th1 response as shown by production of interferon γ and reduction of Th2 response and specifically lowered specific IgE responses and IL-4 in spleen cells... This may be one of the possible mechanisms for IT's anti-inflammatory action... IT was associated with improvement in symptom scores, decrease in rescue medication use, and decreased nasal eosinophilia... In addition to the pathophysiology of upper airway disease, the journal also has thought-provoking articles on therapeutic options that should be of interest to all those researching and taking care of patients with sinonasal diseases... Once again, the May issue of the American Journal of Rhinology and Allergy contains a diverse array of articles in the field of sinonasal diseases that are important in research and clinical care of patients.

Show MeSH
Related in: MedlinePlus