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Editorial: Insights into disease pathogenesis and novel therapeutics.

Ramakrishnan VR - Am J Rhinol Allergy (2014 Mar-Apr)

View Article: PubMed Central - PubMed

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As we strive to advance our understanding and management of sinonasal disorders, the March issue of continues to offer useful information to clinicians and researchers, with an eye towards the future... In general, most patients with sinonasal disorders do fairly well utilizing current practice paradigms... In the current issue, several papers examine disease pathogenesis in chronic rhinosinusitis (CRS) and nasal polyps, in particular with the role of the eosinophil... Much attention has been paid to sublingual immunotherapy (SLIT) in recent years, but SLIT in the pediatric population is an area in need of further evidence... Here Shao et al. provide sorely needed data to indicate that even in children as young as 3 years of age, SLIT can be both safe and efficacious... For instance, Ogawa et al. demonstrate the potential for valproic acid to facilitate olfactory regeneration in a mouse model of olfactory insult, an area where we have relatively few successful options aside from corticosteroid therapy... Indeed, corticosteroids are first-line therapies in many inflammatory disorders, but what can we offer to the subset of patients who do not benefit from them? In steroid-unresponsive CRS patients, postoperative medical therapies are certainly in need of development... Macrolide therapy has been tried in such patients with modest success in the past, possibly due to anti-inflammatory properties beyond the known anti-microbial effects... Maniakis et al. show that the addition of azithromycin to the postoperative medical regimen may result in additional benefits for those patients not satisfactorily managed with topical steroids... Kirtsreesakul et al. examine this in detail, and determine that the peak expiratory flow index is the most appropriate tool to assess nasal patency in allergic rhinitis patients... Irrigation with normal saline is routinely administered post-operatively, and in recent years, more evidence has supported its use... In this issue, we see that electrolyzed water rinses do not have any additional benefit over normal saline rinses after FESS, and that the addition of steroid into rinses does not offer any additional benefit in postoperative healing after endoscopic tumor surgery.

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Vijay R. Ramakrishnan, M.D.
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Editorial: Insights into disease pathogenesis and novel therapeutics.

Ramakrishnan VR - Am J Rhinol Allergy (2014 Mar-Apr)

Vijay R. Ramakrishnan, M.D.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4374135&req=5

FU1: Vijay R. Ramakrishnan, M.D.

View Article: PubMed Central - PubMed

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

As we strive to advance our understanding and management of sinonasal disorders, the March issue of continues to offer useful information to clinicians and researchers, with an eye towards the future... In general, most patients with sinonasal disorders do fairly well utilizing current practice paradigms... In the current issue, several papers examine disease pathogenesis in chronic rhinosinusitis (CRS) and nasal polyps, in particular with the role of the eosinophil... Much attention has been paid to sublingual immunotherapy (SLIT) in recent years, but SLIT in the pediatric population is an area in need of further evidence... Here Shao et al. provide sorely needed data to indicate that even in children as young as 3 years of age, SLIT can be both safe and efficacious... For instance, Ogawa et al. demonstrate the potential for valproic acid to facilitate olfactory regeneration in a mouse model of olfactory insult, an area where we have relatively few successful options aside from corticosteroid therapy... Indeed, corticosteroids are first-line therapies in many inflammatory disorders, but what can we offer to the subset of patients who do not benefit from them? In steroid-unresponsive CRS patients, postoperative medical therapies are certainly in need of development... Macrolide therapy has been tried in such patients with modest success in the past, possibly due to anti-inflammatory properties beyond the known anti-microbial effects... Maniakis et al. show that the addition of azithromycin to the postoperative medical regimen may result in additional benefits for those patients not satisfactorily managed with topical steroids... Kirtsreesakul et al. examine this in detail, and determine that the peak expiratory flow index is the most appropriate tool to assess nasal patency in allergic rhinitis patients... Irrigation with normal saline is routinely administered post-operatively, and in recent years, more evidence has supported its use... In this issue, we see that electrolyzed water rinses do not have any additional benefit over normal saline rinses after FESS, and that the addition of steroid into rinses does not offer any additional benefit in postoperative healing after endoscopic tumor surgery.

Show MeSH