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Editorial: Insight into allergic, rhinologic and skull based pathologies.

Eloy JA - Am J Rhinol Allergy (2014 Jan-Feb)

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Over the past few years, we have witnessed numerous and continuing advances in our understanding of molecular mechanisms facilitating chronic rhinosinusitis (CRS)... The current issue of the contributes further to this area of study... Drilling et al. characterizes the in vitro activity of a bacteriophage cocktail against Staphylococcus aureus biofilms, revealing its effectiveness in eliminating the organism from a substantial portion of clinical isolates in both planktonic and biofilm forms... Hwang and colleagues examine characteristics of H2S in CRS, illustrating its role as an important CRS-associated inflammatory mediator... Luukkainen and colleagues explore the possible mechanisms present in asthma and CRS with nasal polyps among patients residing in urban environments, while Jeong et al. suggest the utility of nasal nitric oxide levels in screening for CRS with polyposis... In their cadaveric study, endoscopic approaches to the lateral orbital apex are explored... The authors conclude that this approach can be considered for patients with irreparably damaged vision and warned that this approach should be considered with caution in patients with intact vision due to the possibility of optic nerve traction... An analysis from the Medical University of South Carolina examined skull base thickness in radiologic images of patients with spontaneous cerebrospinal fluid leaks, finding differences, although it is unclear whether such differences predispose patients to leaks rather than just being a consequence of any underlying pathophysiology... Finally, this issue also contains further study of the relationship between chronic adenoid disease and CRS in the pediatric population, noting that history and physical examination are notoriously unreliable predictors... The wide variety of analyses, ranging from those focusing on basic science and translational research to those containing significant clinical findings that can be immediately applied in medical decision making, offer insight into the expanding knowledge base regarding patients with allergic, rhinologic, and skull base pathologies... Our hope is that these manuscripts will not only prove useful to practicing clinicians and scientists, but offer ideas for further scholarship that will continue to expand our understanding of the complex mechanisms underlying allergic, rhinologic, and skull base disorders.

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Jean Anderson Eloy, MD, FACS
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Editorial: Insight into allergic, rhinologic and skull based pathologies.

Eloy JA - Am J Rhinol Allergy (2014 Jan-Feb)

Jean Anderson Eloy, MD, FACS
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4374134&req=5

FU1: Jean Anderson Eloy, MD, FACS

View Article: PubMed Central - PubMed

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Over the past few years, we have witnessed numerous and continuing advances in our understanding of molecular mechanisms facilitating chronic rhinosinusitis (CRS)... The current issue of the contributes further to this area of study... Drilling et al. characterizes the in vitro activity of a bacteriophage cocktail against Staphylococcus aureus biofilms, revealing its effectiveness in eliminating the organism from a substantial portion of clinical isolates in both planktonic and biofilm forms... Hwang and colleagues examine characteristics of H2S in CRS, illustrating its role as an important CRS-associated inflammatory mediator... Luukkainen and colleagues explore the possible mechanisms present in asthma and CRS with nasal polyps among patients residing in urban environments, while Jeong et al. suggest the utility of nasal nitric oxide levels in screening for CRS with polyposis... In their cadaveric study, endoscopic approaches to the lateral orbital apex are explored... The authors conclude that this approach can be considered for patients with irreparably damaged vision and warned that this approach should be considered with caution in patients with intact vision due to the possibility of optic nerve traction... An analysis from the Medical University of South Carolina examined skull base thickness in radiologic images of patients with spontaneous cerebrospinal fluid leaks, finding differences, although it is unclear whether such differences predispose patients to leaks rather than just being a consequence of any underlying pathophysiology... Finally, this issue also contains further study of the relationship between chronic adenoid disease and CRS in the pediatric population, noting that history and physical examination are notoriously unreliable predictors... The wide variety of analyses, ranging from those focusing on basic science and translational research to those containing significant clinical findings that can be immediately applied in medical decision making, offer insight into the expanding knowledge base regarding patients with allergic, rhinologic, and skull base pathologies... Our hope is that these manuscripts will not only prove useful to practicing clinicians and scientists, but offer ideas for further scholarship that will continue to expand our understanding of the complex mechanisms underlying allergic, rhinologic, and skull base disorders.

Show MeSH