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Urine L-carnitine excretion in hypertensive adolescents.

Kępka A, Kuroczycka-Saniutycz E, Chojnowska S, Fiłonowicz R, Korzeniecka-Kozerska A, Wasilewska A - Ir J Med Sci (2014)

Bottom Line: The results of this study do not explain the increased urine levels of L-carnitine.It is possible to hypothesize that in hypertensive adolescents subclinical kidney dysfunction occurs.It is proposed that studies examining the concurrent plasma and urine concentration of L-carnitine and correlation with acknowledged proximal tubular markers are needed.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry, Radioimmunology and Experimental Medicine, The Children's Memorial Health Institute, Warsaw, Poland.

ABSTRACT

Aim: This study was performed to test the hypothesis that urinary levels of L-carnitine and its derivatives are enhanced in children and adolescents with hypertension and also check if analyzed parameters may serve as early markers of subclinical renal damage.

Methods: The study included 112 children and adolescents (67 males and 45 females) aged median 10-18 years. Participants were divided into two groups: HT-64 subjects with confirmed primary hypertension and R-reference group-48 subjects with white-coat hypertension. Urinary Free and Total L-carnitine were determined by the enzymatic method of Cederblad. The L-carnitine levels were expressed as urinary ratio in micromole per gram creatinine (μmol/g).

Results: The urinary excretion of Total and Free L-carnitine was significantly higher in hypertensive adolescents in comparison to reference group-white coat hypertension. Other important findings were positive correlations between Free L-carnitine/cr., Total L-carnitine/cr. ratio and serum uric acid level, serum cholesterol level and systolic blood pressure.

Conclusion: The results of this study do not explain the increased urine levels of L-carnitine. The most likely reason for excessive urinary loss was disturbed renal tubular reabsorption. It is possible to hypothesize that in hypertensive adolescents subclinical kidney dysfunction occurs. It is proposed that studies examining the concurrent plasma and urine concentration of L-carnitine and correlation with acknowledged proximal tubular markers are needed.

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Related in: MedlinePlus

Linear regression analysis demonstrating the relationship between Free l-carnitine/cr., Total l-carnitine/cr. ratio and a serum uric acid level, b serum cholesterol level and c mean systolic blood pressure during 24 h, d daytime SBP loads
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Fig1: Linear regression analysis demonstrating the relationship between Free l-carnitine/cr., Total l-carnitine/cr. ratio and a serum uric acid level, b serum cholesterol level and c mean systolic blood pressure during 24 h, d daytime SBP loads

Mentions: We performed single regression and correlation analyses of urine parameters with anthropometric, clinical and metabolic measurement and found a significant correlation between the urine Free LC/cr., Total LC/cr. ratio and serum uric acid level (r = 0.22, p < 0.05; r = 0.20, p < 0.05, respectively) and serum cholesterol level (r = 0.25, p < 0.05; r = 0.21, p < 0.05, respectively) (Fig. 1). The Free LC, Total LC and Acylcarnitine levels were not correlated with age, height, body weight, BMI, hemoglobin concentration, RBC, serum alanine transaminase, aspartate transaminase (AST), serum creatinine levels, serum levels of triglycerides, HDL-cholesterol and LDL-cholesterol.


Urine L-carnitine excretion in hypertensive adolescents.

Kępka A, Kuroczycka-Saniutycz E, Chojnowska S, Fiłonowicz R, Korzeniecka-Kozerska A, Wasilewska A - Ir J Med Sci (2014)

Linear regression analysis demonstrating the relationship between Free l-carnitine/cr., Total l-carnitine/cr. ratio and a serum uric acid level, b serum cholesterol level and c mean systolic blood pressure during 24 h, d daytime SBP loads
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4374118&req=5

Fig1: Linear regression analysis demonstrating the relationship between Free l-carnitine/cr., Total l-carnitine/cr. ratio and a serum uric acid level, b serum cholesterol level and c mean systolic blood pressure during 24 h, d daytime SBP loads
Mentions: We performed single regression and correlation analyses of urine parameters with anthropometric, clinical and metabolic measurement and found a significant correlation between the urine Free LC/cr., Total LC/cr. ratio and serum uric acid level (r = 0.22, p < 0.05; r = 0.20, p < 0.05, respectively) and serum cholesterol level (r = 0.25, p < 0.05; r = 0.21, p < 0.05, respectively) (Fig. 1). The Free LC, Total LC and Acylcarnitine levels were not correlated with age, height, body weight, BMI, hemoglobin concentration, RBC, serum alanine transaminase, aspartate transaminase (AST), serum creatinine levels, serum levels of triglycerides, HDL-cholesterol and LDL-cholesterol.

Bottom Line: The results of this study do not explain the increased urine levels of L-carnitine.It is possible to hypothesize that in hypertensive adolescents subclinical kidney dysfunction occurs.It is proposed that studies examining the concurrent plasma and urine concentration of L-carnitine and correlation with acknowledged proximal tubular markers are needed.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry, Radioimmunology and Experimental Medicine, The Children's Memorial Health Institute, Warsaw, Poland.

ABSTRACT

Aim: This study was performed to test the hypothesis that urinary levels of L-carnitine and its derivatives are enhanced in children and adolescents with hypertension and also check if analyzed parameters may serve as early markers of subclinical renal damage.

Methods: The study included 112 children and adolescents (67 males and 45 females) aged median 10-18 years. Participants were divided into two groups: HT-64 subjects with confirmed primary hypertension and R-reference group-48 subjects with white-coat hypertension. Urinary Free and Total L-carnitine were determined by the enzymatic method of Cederblad. The L-carnitine levels were expressed as urinary ratio in micromole per gram creatinine (μmol/g).

Results: The urinary excretion of Total and Free L-carnitine was significantly higher in hypertensive adolescents in comparison to reference group-white coat hypertension. Other important findings were positive correlations between Free L-carnitine/cr., Total L-carnitine/cr. ratio and serum uric acid level, serum cholesterol level and systolic blood pressure.

Conclusion: The results of this study do not explain the increased urine levels of L-carnitine. The most likely reason for excessive urinary loss was disturbed renal tubular reabsorption. It is possible to hypothesize that in hypertensive adolescents subclinical kidney dysfunction occurs. It is proposed that studies examining the concurrent plasma and urine concentration of L-carnitine and correlation with acknowledged proximal tubular markers are needed.

Show MeSH
Related in: MedlinePlus