Spread of artemisinin-resistant Plasmodium falciparum in Myanmar: a cross-sectional survey of the K13 molecular marker.
Bottom Line: Artemisinin resistance extends across much of Myanmar.Appropriate therapeutic regimens should be tested urgently and implemented comprehensively if spread of artemisinin resistance to other regions is to be avoided.Wellcome Trust-Mahidol University-Oxford Tropical Medicine Research Programme and the Bill & Melinda Gates Foundation.
Affiliation: Myanmar Oxford Clinical Research Unit, Yangon, Myanmar; Defence Services Medical Research Centre, Naypyitaw, Myanmar.Show MeSH
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Mentions: We calculated the total prevalence of K13-propeller mutations for each administrative region (table) and site as the proportion of samples with any mutation after aminoacid 440. We entered these point metrics into two independent geospatial models to obtain continuous prevalence maps for Myanmar (figure 4). Both maps showed a large area of fairly high mutation prevalence (substantially more than 10%) extending from the southeast to the north of the country (figure 4). Much of Lower Myanmar, and Chin and Rakhine states in the west, had a very low prevalence of K13 mutations, a finding consistent with the absence of K13 mutant parasites in adjacent Bangladesh (figure 4).
Affiliation: Myanmar Oxford Clinical Research Unit, Yangon, Myanmar; Defence Services Medical Research Centre, Naypyitaw, Myanmar.