Spread of artemisinin-resistant Plasmodium falciparum in Myanmar: a cross-sectional survey of the K13 molecular marker.
Bottom Line: Artemisinin resistance extends across much of Myanmar.Appropriate therapeutic regimens should be tested urgently and implemented comprehensively if spread of artemisinin resistance to other regions is to be avoided.Wellcome Trust-Mahidol University-Oxford Tropical Medicine Research Programme and the Bill & Melinda Gates Foundation.
Affiliation: Myanmar Oxford Clinical Research Unit, Yangon, Myanmar; Defence Services Medical Research Centre, Naypyitaw, Myanmar.Show MeSH
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Mentions: We identified 29 different mutations after aminoacid 210, of which 26 (90%) were after aminoacid 440 (appendix). 371 (39%) isolates had a propeller-domain mutation (table). Consistent with previous reports,4,5 these mutations were concentrated within propeller blades 1–4 (figure 2). 17 isolates had an E252Q mutation in the so-called stem section of the K13 protein; one (2%) from Bago Region, 11 (4%) from Kayin State, and five (3%) from Tak Province. No sample had more than one mutation in these conserved domains of the protein.
Affiliation: Myanmar Oxford Clinical Research Unit, Yangon, Myanmar; Defence Services Medical Research Centre, Naypyitaw, Myanmar.