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Effectiveness of a monovalent rotavirus vaccine in infants in Malawi after programmatic roll-out: an observational and case-control study.

Bar-Zeev N, Kapanda L, Tate JE, Jere KC, Iturriza-Gomara M, Nakagomi O, Mwansambo C, Costello A, Parashar UD, Heyderman RS, French N, Cunliffe NA, VacSurv Consorti - Lancet Infect Dis (2015)

Bottom Line: In the first half of 2012, incidence of rotavirus hospital admission was 269 per 100,000 infants compared with 284 in the same months of 2013 (rise of 5·8%, 95% CI -23·1 to 45·4; p=0·73) and 153 in these months in 2014 (a reduction from the prevaccine period of 43·2%, 18·0-60·7; p=0·003).The point estimate of effectiveness was higher against genotype G1 than against G2 and G12.Routine use of RV1 reduced hospital admissions for several genotypes of rotavirus in children younger than 5 years, especially in infants younger than 1 year.

View Article: PubMed Central - PubMed

Affiliation: Malawi-Liverpool-Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, Blantyre, Malawi; Institute of Infection and Global Health, University of Liverpool, Liverpool, UK.

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Rotavirus VP7 (G) genotypes detected by month in children younger than 5 years of age presenting to Queen Elizabeth Central Hospital, Blantyre, from Jan 1, 2012, to June 30, 2014Graph excludes mixed infection.
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fig2: Rotavirus VP7 (G) genotypes detected by month in children younger than 5 years of age presenting to Queen Elizabeth Central Hospital, Blantyre, from Jan 1, 2012, to June 30, 2014Graph excludes mixed infection.

Mentions: Before vaccine introduction (Jan 1, 2012, to Oct 28, 2012), we collected 419 stool samples, of which 185 (44%) were positive for rotavirus (figure 1). After vaccine introduction (Oct 29, 2012, to June 30, 2014), we collected 998 stool samples, of which 318 (32%) were rotavirus positive (figure 1, appendix). Of 472 rotaviruses we examined from Jan 1, 2012, to June 30, 2014, prevalent genotypes included G2P[4] (117; 25%), G1P[8] (101; 21%), G12P[6] (48; 10%), and G2P[6] (47; 10%). 122 (26%) rotaviruses contained mixed G or P types or both (appendix). Genotype G1 was most common in the first year after the introduction of the vaccine, whereas genotype G2 dominated in the second year (figure 2).


Effectiveness of a monovalent rotavirus vaccine in infants in Malawi after programmatic roll-out: an observational and case-control study.

Bar-Zeev N, Kapanda L, Tate JE, Jere KC, Iturriza-Gomara M, Nakagomi O, Mwansambo C, Costello A, Parashar UD, Heyderman RS, French N, Cunliffe NA, VacSurv Consorti - Lancet Infect Dis (2015)

Rotavirus VP7 (G) genotypes detected by month in children younger than 5 years of age presenting to Queen Elizabeth Central Hospital, Blantyre, from Jan 1, 2012, to June 30, 2014Graph excludes mixed infection.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4374102&req=5

fig2: Rotavirus VP7 (G) genotypes detected by month in children younger than 5 years of age presenting to Queen Elizabeth Central Hospital, Blantyre, from Jan 1, 2012, to June 30, 2014Graph excludes mixed infection.
Mentions: Before vaccine introduction (Jan 1, 2012, to Oct 28, 2012), we collected 419 stool samples, of which 185 (44%) were positive for rotavirus (figure 1). After vaccine introduction (Oct 29, 2012, to June 30, 2014), we collected 998 stool samples, of which 318 (32%) were rotavirus positive (figure 1, appendix). Of 472 rotaviruses we examined from Jan 1, 2012, to June 30, 2014, prevalent genotypes included G2P[4] (117; 25%), G1P[8] (101; 21%), G12P[6] (48; 10%), and G2P[6] (47; 10%). 122 (26%) rotaviruses contained mixed G or P types or both (appendix). Genotype G1 was most common in the first year after the introduction of the vaccine, whereas genotype G2 dominated in the second year (figure 2).

Bottom Line: In the first half of 2012, incidence of rotavirus hospital admission was 269 per 100,000 infants compared with 284 in the same months of 2013 (rise of 5·8%, 95% CI -23·1 to 45·4; p=0·73) and 153 in these months in 2014 (a reduction from the prevaccine period of 43·2%, 18·0-60·7; p=0·003).The point estimate of effectiveness was higher against genotype G1 than against G2 and G12.Routine use of RV1 reduced hospital admissions for several genotypes of rotavirus in children younger than 5 years, especially in infants younger than 1 year.

View Article: PubMed Central - PubMed

Affiliation: Malawi-Liverpool-Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, Blantyre, Malawi; Institute of Infection and Global Health, University of Liverpool, Liverpool, UK.

Show MeSH
Related in: MedlinePlus