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Telocytes accompanying cardiomyocyte in primary culture: two- and three-dimensional culture environment.

Zhou J, Zhang Y, Wen X, Cao J, Li D, Lin Q, Wang H, Liu Z, Duan C, Wu K, Wang C - J. Cell. Mol. Med. (2010)

Bottom Line: Noteworthy, telocytes seem to play a significant role in the normal function and regeneration of myocardium.The results showed that typical telocytes are distributed among cardiomyocytes, connecting them by long telopodes.Also, a significant number of vimentin+ telocytes were present within engineered heart tissue.

View Article: PubMed Central - PubMed

Affiliation: Department of Tissue Engineering, Institute of Basic Medical Sciences and Tissue Engineering Research Center, Academy of Military Medical Sciences, Beijing, People's Republic of China.

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Immunohistochemical staining for CD34+ cells in engineered heart at day 14. Arrow shows a CD34+ telocyte in engineered heart tissue. Bar = 20 μm.
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fig08: Immunohistochemical staining for CD34+ cells in engineered heart at day 14. Arrow shows a CD34+ telocyte in engineered heart tissue. Bar = 20 μm.

Mentions: We used immunohistochemical staining for antigens expressed in telocytes: c-kit, CD34 and vimentin. c-kit or CD34+ telocytes existed in engineered heart tissue with long cell processes (Figs 7 and 8). In addition, a number of vimentin+ cells were observed in engineered heart tissues (Fig. 9A). Among these cells, telocytes appeared with long and extremely thin telopodes. Vimentin is discontinuously expressed along these telopodes (Fig. 9B), presumably due to the tortuous telopodes’ three-dimensional path.


Telocytes accompanying cardiomyocyte in primary culture: two- and three-dimensional culture environment.

Zhou J, Zhang Y, Wen X, Cao J, Li D, Lin Q, Wang H, Liu Z, Duan C, Wu K, Wang C - J. Cell. Mol. Med. (2010)

Immunohistochemical staining for CD34+ cells in engineered heart at day 14. Arrow shows a CD34+ telocyte in engineered heart tissue. Bar = 20 μm.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4373485&req=5

fig08: Immunohistochemical staining for CD34+ cells in engineered heart at day 14. Arrow shows a CD34+ telocyte in engineered heart tissue. Bar = 20 μm.
Mentions: We used immunohistochemical staining for antigens expressed in telocytes: c-kit, CD34 and vimentin. c-kit or CD34+ telocytes existed in engineered heart tissue with long cell processes (Figs 7 and 8). In addition, a number of vimentin+ cells were observed in engineered heart tissues (Fig. 9A). Among these cells, telocytes appeared with long and extremely thin telopodes. Vimentin is discontinuously expressed along these telopodes (Fig. 9B), presumably due to the tortuous telopodes’ three-dimensional path.

Bottom Line: Noteworthy, telocytes seem to play a significant role in the normal function and regeneration of myocardium.The results showed that typical telocytes are distributed among cardiomyocytes, connecting them by long telopodes.Also, a significant number of vimentin+ telocytes were present within engineered heart tissue.

View Article: PubMed Central - PubMed

Affiliation: Department of Tissue Engineering, Institute of Basic Medical Sciences and Tissue Engineering Research Center, Academy of Military Medical Sciences, Beijing, People's Republic of China.

Show MeSH