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Telocytes accompanying cardiomyocyte in primary culture: two- and three-dimensional culture environment.

Zhou J, Zhang Y, Wen X, Cao J, Li D, Lin Q, Wang H, Liu Z, Duan C, Wu K, Wang C - J. Cell. Mol. Med. (2010)

Bottom Line: Noteworthy, telocytes seem to play a significant role in the normal function and regeneration of myocardium.The results showed that typical telocytes are distributed among cardiomyocytes, connecting them by long telopodes.Also, a significant number of vimentin+ telocytes were present within engineered heart tissue.

View Article: PubMed Central - PubMed

Affiliation: Department of Tissue Engineering, Institute of Basic Medical Sciences and Tissue Engineering Research Center, Academy of Military Medical Sciences, Beijing, People's Republic of China.

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Telocytes in primary culture at day 7. (A) Extremely long and thin prolongations – telopodes (arrow) extended from the body of telocytes. (B) Typical moniliform prolongations (arrows): alternation of thin segments – podomeres – and dilated segments – podoms. Bar = 50 μm.
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fig02: Telocytes in primary culture at day 7. (A) Extremely long and thin prolongations – telopodes (arrow) extended from the body of telocytes. (B) Typical moniliform prolongations (arrows): alternation of thin segments – podomeres – and dilated segments – podoms. Bar = 50 μm.

Mentions: In primary culture of cardiomyocytes isolated from myocardial tissues, the typical telocytes were detected. They have a fusiform cell body and two long prolongations (Fig. 1A). The morphology of telocytes in vitro is different from cardiac cells. After 7 days of culture, typical morphological features of telocytes appeared under light microscope: a small oval-shaped cell body with extremely long and thin moniliform prolongations (telopodes) extended from the cell body (Figs. 1 and 2). Telocytes often accompanied the cardiomyocytes and their telopodes ended up on cardiomyocytes. However, telocytes with their long prolongations interconnected cardiomyocytes and accelerated their synchronously beating (Figs. 3 and 4 and Movie S1).


Telocytes accompanying cardiomyocyte in primary culture: two- and three-dimensional culture environment.

Zhou J, Zhang Y, Wen X, Cao J, Li D, Lin Q, Wang H, Liu Z, Duan C, Wu K, Wang C - J. Cell. Mol. Med. (2010)

Telocytes in primary culture at day 7. (A) Extremely long and thin prolongations – telopodes (arrow) extended from the body of telocytes. (B) Typical moniliform prolongations (arrows): alternation of thin segments – podomeres – and dilated segments – podoms. Bar = 50 μm.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4373485&req=5

fig02: Telocytes in primary culture at day 7. (A) Extremely long and thin prolongations – telopodes (arrow) extended from the body of telocytes. (B) Typical moniliform prolongations (arrows): alternation of thin segments – podomeres – and dilated segments – podoms. Bar = 50 μm.
Mentions: In primary culture of cardiomyocytes isolated from myocardial tissues, the typical telocytes were detected. They have a fusiform cell body and two long prolongations (Fig. 1A). The morphology of telocytes in vitro is different from cardiac cells. After 7 days of culture, typical morphological features of telocytes appeared under light microscope: a small oval-shaped cell body with extremely long and thin moniliform prolongations (telopodes) extended from the cell body (Figs. 1 and 2). Telocytes often accompanied the cardiomyocytes and their telopodes ended up on cardiomyocytes. However, telocytes with their long prolongations interconnected cardiomyocytes and accelerated their synchronously beating (Figs. 3 and 4 and Movie S1).

Bottom Line: Noteworthy, telocytes seem to play a significant role in the normal function and regeneration of myocardium.The results showed that typical telocytes are distributed among cardiomyocytes, connecting them by long telopodes.Also, a significant number of vimentin+ telocytes were present within engineered heart tissue.

View Article: PubMed Central - PubMed

Affiliation: Department of Tissue Engineering, Institute of Basic Medical Sciences and Tissue Engineering Research Center, Academy of Military Medical Sciences, Beijing, People's Republic of China.

Show MeSH
Related in: MedlinePlus