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Does autophagy take a front seat in lifespan extension?

Petrovski G, Das DK - J. Cell. Mol. Med. (2010)

Bottom Line: Components of anti-ageing and autophagy include SirTs and FoxOs.Nutritional deprivation or calorie restriction as well as several nutriceuticals including resveratrol, spermidine, curcumin and piperine can enhance autophagy and increase lifespan.Such striking similarities indicate that lifespan is strongly dependent on autophagy.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry and Molecular Biology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary.

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Similarity in the signalling pathways of autophagy and ageing. AMPK, AMP-activated protein kinase; IGF, insulin-like growth factor; mTOR, mammalian target of rapamycin; PKA, protein kinase A; Sch9, Saccharomyces cerevisiae kinase 9.
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fig04: Similarity in the signalling pathways of autophagy and ageing. AMPK, AMP-activated protein kinase; IGF, insulin-like growth factor; mTOR, mammalian target of rapamycin; PKA, protein kinase A; Sch9, Saccharomyces cerevisiae kinase 9.

Mentions: Before discussing pharmacological manipulation to enhance autophagy, it is necessary to understand the signalling processes for autophagy regulation (Fig. 3). Interestingly, there is striking similarities in the signalling pathways between autophagy and ageing (Fig. 4).


Does autophagy take a front seat in lifespan extension?

Petrovski G, Das DK - J. Cell. Mol. Med. (2010)

Similarity in the signalling pathways of autophagy and ageing. AMPK, AMP-activated protein kinase; IGF, insulin-like growth factor; mTOR, mammalian target of rapamycin; PKA, protein kinase A; Sch9, Saccharomyces cerevisiae kinase 9.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4373474&req=5

fig04: Similarity in the signalling pathways of autophagy and ageing. AMPK, AMP-activated protein kinase; IGF, insulin-like growth factor; mTOR, mammalian target of rapamycin; PKA, protein kinase A; Sch9, Saccharomyces cerevisiae kinase 9.
Mentions: Before discussing pharmacological manipulation to enhance autophagy, it is necessary to understand the signalling processes for autophagy regulation (Fig. 3). Interestingly, there is striking similarities in the signalling pathways between autophagy and ageing (Fig. 4).

Bottom Line: Components of anti-ageing and autophagy include SirTs and FoxOs.Nutritional deprivation or calorie restriction as well as several nutriceuticals including resveratrol, spermidine, curcumin and piperine can enhance autophagy and increase lifespan.Such striking similarities indicate that lifespan is strongly dependent on autophagy.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry and Molecular Biology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary.

Show MeSH