Limits...
Does autophagy take a front seat in lifespan extension?

Petrovski G, Das DK - J. Cell. Mol. Med. (2010)

Bottom Line: Components of anti-ageing and autophagy include SirTs and FoxOs.Nutritional deprivation or calorie restriction as well as several nutriceuticals including resveratrol, spermidine, curcumin and piperine can enhance autophagy and increase lifespan.Such striking similarities indicate that lifespan is strongly dependent on autophagy.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry and Molecular Biology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary.

Show MeSH

Related in: MedlinePlus

Signalling cascades regulating autophagy. AAT, area at risk; AMPK, AMP-activated protein kinase; FoxO, forkhead box; IGF, insulin-like growth factor; LKBI, tumour suppressor kinase; PI3K, phosphatidylinositol 3-kinase; SirT, Sirtuin; eE2F, eukaryotic elongation factor 2F; eIF4F, eukaryotic translation initiation factor 4F.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4373474&req=5

fig03: Signalling cascades regulating autophagy. AAT, area at risk; AMPK, AMP-activated protein kinase; FoxO, forkhead box; IGF, insulin-like growth factor; LKBI, tumour suppressor kinase; PI3K, phosphatidylinositol 3-kinase; SirT, Sirtuin; eE2F, eukaryotic elongation factor 2F; eIF4F, eukaryotic translation initiation factor 4F.

Mentions: Before discussing pharmacological manipulation to enhance autophagy, it is necessary to understand the signalling processes for autophagy regulation (Fig. 3). Interestingly, there is striking similarities in the signalling pathways between autophagy and ageing (Fig. 4).


Does autophagy take a front seat in lifespan extension?

Petrovski G, Das DK - J. Cell. Mol. Med. (2010)

Signalling cascades regulating autophagy. AAT, area at risk; AMPK, AMP-activated protein kinase; FoxO, forkhead box; IGF, insulin-like growth factor; LKBI, tumour suppressor kinase; PI3K, phosphatidylinositol 3-kinase; SirT, Sirtuin; eE2F, eukaryotic elongation factor 2F; eIF4F, eukaryotic translation initiation factor 4F.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4373474&req=5

fig03: Signalling cascades regulating autophagy. AAT, area at risk; AMPK, AMP-activated protein kinase; FoxO, forkhead box; IGF, insulin-like growth factor; LKBI, tumour suppressor kinase; PI3K, phosphatidylinositol 3-kinase; SirT, Sirtuin; eE2F, eukaryotic elongation factor 2F; eIF4F, eukaryotic translation initiation factor 4F.
Mentions: Before discussing pharmacological manipulation to enhance autophagy, it is necessary to understand the signalling processes for autophagy regulation (Fig. 3). Interestingly, there is striking similarities in the signalling pathways between autophagy and ageing (Fig. 4).

Bottom Line: Components of anti-ageing and autophagy include SirTs and FoxOs.Nutritional deprivation or calorie restriction as well as several nutriceuticals including resveratrol, spermidine, curcumin and piperine can enhance autophagy and increase lifespan.Such striking similarities indicate that lifespan is strongly dependent on autophagy.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry and Molecular Biology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary.

Show MeSH
Related in: MedlinePlus