Epigenetic inactivation of the hsa-miR-203 in haematological malignancies.
Bottom Line: In CLL, hsa-miR-203 methylation was associated with a higher presenting Hb level (P = 0.033).In conclusion, miR-203, a tumour suppressor gene, was hypermethylated in a tumour-specific manner with gene silencing. hsa-miR-203 was more frequently hypermethylated in lymphoid than myeloid malignancies.In NHL, hsa-miR-203 methylation was associated with concomitant methylation of other tumour suppressor miRNAs.
Affiliation: Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China. firstname.lastname@example.orgShow MeSH
Related in: MedlinePlus
Mentions: JEKO-1 cells were completely methylated for hsa-miR-203. Upon 5-AzadC demethylation treatment, hsa-miR-203 U-MSP signal emerged on day 3 (Fig. 3A), with re-expression of mature miR-203 as shown by Taqman stem-loop RT-qPCR (Fig. 3B).
Affiliation: Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China. email@example.com