Palmitoylethanolamide counteracts reactive astrogliosis induced by β-amyloid peptide.
Bottom Line: This effect was reduced by PPAR-α antagonist.Moreover, this ALIAmide, like Aβ, increased 2-AG levels.These results indicate that PEA exhibits anti-inflammatory properties able to counteract Aβ-induced astrogliosis, and suggest novel treatment for neuroinflammatory/ neurodegenerative processes.
Affiliation: Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy.Show MeSH
Related in: MedlinePlus
Mentions: Additional experiments were aimed at investigating whether exposure to Aβ was able to affect PPAR transcription and expression. RT-PCR and Western blot analyses revealed that Aβ significantly down-regulated PPAR-α, but not PPAR-γ, transcription and expression. In the same experimental conditions, PEA was able to counteract the above reported alterations induced by Aβ (Fig. 6).
Affiliation: Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy.