Palmitoylethanolamide counteracts reactive astrogliosis induced by β-amyloid peptide.
Bottom Line: Experiments were carried out to investigate PEA's (10(-7) M) effects upon the expression and release of pro-inflammatory molecules in rat primary astrocytes activated by soluble Aβ(1-42) (1 μg/ml) as well as to identify mechanisms responsible for such actions.This effect was reduced by PPAR-α antagonist.Moreover, this ALIAmide, like Aβ, increased 2-AG levels.
Affiliation: Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy.Show MeSH
Related in: MedlinePlus
Mentions: Additional experiments were aimed at investigating whether exposure to Aβ was able to affect PPAR transcription and expression. RT-PCR and Western blot analyses revealed that Aβ significantly down-regulated PPAR-α, but not PPAR-γ, transcription and expression. In the same experimental conditions, PEA was able to counteract the above reported alterations induced by Aβ (Fig. 6).
Affiliation: Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy.