Palmitoylethanolamide counteracts reactive astrogliosis induced by β-amyloid peptide.
Bottom Line: This effect was reduced by PPAR-α antagonist.Moreover, this ALIAmide, like Aβ, increased 2-AG levels.These results indicate that PEA exhibits anti-inflammatory properties able to counteract Aβ-induced astrogliosis, and suggest novel treatment for neuroinflammatory/ neurodegenerative processes.
Affiliation: Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy.Show MeSH
Related in: MedlinePlus
Mentions: Another set of experiments was aimed at assessing the effect of PEA on the production of inflammatory factors induced by Aβ. Treatment with Aβ for 24 hrs resulted in a significant increase in iNOS and COX-2 expression, as determined by Western blot and immunofluorescence analyses. Such protein increase paralleled nitric oxide, IL-1β, TNF-α and PGE2 up-release, as determined by Griess reaction and ELISA experiments. Also in this case PEA antagonized the enhancement of both expression and release of all pro-inflammatory molecules detected, and the blockade of PPAR-α with MK886 partly attenuated these effects (Figs 2 and 3).
Affiliation: Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy.