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Histamine and H1 -histamine receptors faster venous circulation.

Galajda Z, Balla J, Szentmiklosi AJ, Biro T, Czifra G, Dobrosi N, Cseppento A, Patonay L, Roszer T, Balla G, Popescu LM, Lekli I, Tosaki A - J. Cell. Mol. Med. (2011)

Bottom Line: Voltage-dependent calcium channels mediated mainly the histamine-induced force generation of saphenous vein, whereas it did not act in the inferior vena cava.Furthermore, a significantly greater histamine immunopositivity was detected in veins after stretching compared to the resting state.We conclude that histamine receptor density adapts to the actual requirements of the circulation, and histamine liberated by the venous wall during increased venous pressure contributes to the contraction of vessels, providing a force for the venous return.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Institute of Vascular Surgery, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary.

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H1 histamine receptor expression in various rabbit veins. (A) Specific H1 immunopositive bands at ∼55 kD of a representative immunoblot and corresponding CytC staining. (B) Optical density of H1 immunopositive bands, normalized to CytC. n ≥ 3 in each group.
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fig04: H1 histamine receptor expression in various rabbit veins. (A) Specific H1 immunopositive bands at ∼55 kD of a representative immunoblot and corresponding CytC staining. (B) Optical density of H1 immunopositive bands, normalized to CytC. n ≥ 3 in each group.

Mentions: H1-histamine receptors were expressed in high density in saphenous vein and inferior vena cava, whereas expression level of these receptors was low in internal iliac vein and right and left superior vena cavas (Fig. 4).


Histamine and H1 -histamine receptors faster venous circulation.

Galajda Z, Balla J, Szentmiklosi AJ, Biro T, Czifra G, Dobrosi N, Cseppento A, Patonay L, Roszer T, Balla G, Popescu LM, Lekli I, Tosaki A - J. Cell. Mol. Med. (2011)

H1 histamine receptor expression in various rabbit veins. (A) Specific H1 immunopositive bands at ∼55 kD of a representative immunoblot and corresponding CytC staining. (B) Optical density of H1 immunopositive bands, normalized to CytC. n ≥ 3 in each group.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4373430&req=5

fig04: H1 histamine receptor expression in various rabbit veins. (A) Specific H1 immunopositive bands at ∼55 kD of a representative immunoblot and corresponding CytC staining. (B) Optical density of H1 immunopositive bands, normalized to CytC. n ≥ 3 in each group.
Mentions: H1-histamine receptors were expressed in high density in saphenous vein and inferior vena cava, whereas expression level of these receptors was low in internal iliac vein and right and left superior vena cavas (Fig. 4).

Bottom Line: Voltage-dependent calcium channels mediated mainly the histamine-induced force generation of saphenous vein, whereas it did not act in the inferior vena cava.Furthermore, a significantly greater histamine immunopositivity was detected in veins after stretching compared to the resting state.We conclude that histamine receptor density adapts to the actual requirements of the circulation, and histamine liberated by the venous wall during increased venous pressure contributes to the contraction of vessels, providing a force for the venous return.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Institute of Vascular Surgery, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary.

Show MeSH
Related in: MedlinePlus