Histamine and H1 -histamine receptors faster venous circulation.
Bottom Line: Voltage-dependent calcium channels mediated mainly the histamine-induced force generation of saphenous vein, whereas it did not act in the inferior vena cava.Importantly, transient clamping of the femoral vein in animals caused a short-term constriction, which was inhibited by H(1) -histamine receptor antagonist in vivo.Furthermore, a significantly greater histamine immunopositivity was detected in veins after stretching compared to the resting state.
Affiliation: Department of Surgery, Institute of Vascular Surgery, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary.Show MeSH
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Mentions: H1-histamine receptors were expressed in high density in saphenous vein and inferior vena cava, whereas expression level of these receptors was low in internal iliac vein and right and left superior vena cavas (Fig. 4).
Affiliation: Department of Surgery, Institute of Vascular Surgery, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary.