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Histamine and H1 -histamine receptors faster venous circulation.

Galajda Z, Balla J, Szentmiklosi AJ, Biro T, Czifra G, Dobrosi N, Cseppento A, Patonay L, Roszer T, Balla G, Popescu LM, Lekli I, Tosaki A - J. Cell. Mol. Med. (2011)

Bottom Line: Voltage-dependent calcium channels mediated mainly the histamine-induced force generation of saphenous vein, whereas it did not act in the inferior vena cava.Furthermore, a significantly greater histamine immunopositivity was detected in veins after stretching compared to the resting state.We conclude that histamine receptor density adapts to the actual requirements of the circulation, and histamine liberated by the venous wall during increased venous pressure contributes to the contraction of vessels, providing a force for the venous return.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Institute of Vascular Surgery, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary.

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Histamine-induced contraction in isolated rabbit vessels. Abdominal part (open circle) of inferior vena cava (n = 10), common iliac vein (full circle) (n = 5), intrathoracic part (open square) of inferior vena cava (n = 7). The histamine-induced increases in tension are normalized for vessel cross-sectional area, and absolute values of the increase in tension are shown. Data represent mean ± S.E.M.
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fig02: Histamine-induced contraction in isolated rabbit vessels. Abdominal part (open circle) of inferior vena cava (n = 10), common iliac vein (full circle) (n = 5), intrathoracic part (open square) of inferior vena cava (n = 7). The histamine-induced increases in tension are normalized for vessel cross-sectional area, and absolute values of the increase in tension are shown. Data represent mean ± S.E.M.


Histamine and H1 -histamine receptors faster venous circulation.

Galajda Z, Balla J, Szentmiklosi AJ, Biro T, Czifra G, Dobrosi N, Cseppento A, Patonay L, Roszer T, Balla G, Popescu LM, Lekli I, Tosaki A - J. Cell. Mol. Med. (2011)

Histamine-induced contraction in isolated rabbit vessels. Abdominal part (open circle) of inferior vena cava (n = 10), common iliac vein (full circle) (n = 5), intrathoracic part (open square) of inferior vena cava (n = 7). The histamine-induced increases in tension are normalized for vessel cross-sectional area, and absolute values of the increase in tension are shown. Data represent mean ± S.E.M.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4373430&req=5

fig02: Histamine-induced contraction in isolated rabbit vessels. Abdominal part (open circle) of inferior vena cava (n = 10), common iliac vein (full circle) (n = 5), intrathoracic part (open square) of inferior vena cava (n = 7). The histamine-induced increases in tension are normalized for vessel cross-sectional area, and absolute values of the increase in tension are shown. Data represent mean ± S.E.M.
Bottom Line: Voltage-dependent calcium channels mediated mainly the histamine-induced force generation of saphenous vein, whereas it did not act in the inferior vena cava.Furthermore, a significantly greater histamine immunopositivity was detected in veins after stretching compared to the resting state.We conclude that histamine receptor density adapts to the actual requirements of the circulation, and histamine liberated by the venous wall during increased venous pressure contributes to the contraction of vessels, providing a force for the venous return.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Institute of Vascular Surgery, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary.

Show MeSH
Related in: MedlinePlus