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Histamine and H1 -histamine receptors faster venous circulation.

Galajda Z, Balla J, Szentmiklosi AJ, Biro T, Czifra G, Dobrosi N, Cseppento A, Patonay L, Roszer T, Balla G, Popescu LM, Lekli I, Tosaki A - J. Cell. Mol. Med. (2011)

Bottom Line: Voltage-dependent calcium channels mediated mainly the histamine-induced force generation of saphenous vein, whereas it did not act in the inferior vena cava.Furthermore, a significantly greater histamine immunopositivity was detected in veins after stretching compared to the resting state.We conclude that histamine receptor density adapts to the actual requirements of the circulation, and histamine liberated by the venous wall during increased venous pressure contributes to the contraction of vessels, providing a force for the venous return.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Institute of Vascular Surgery, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary.

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Histamine-induced contraction in isolated rabbit vessels. Saphenous vein (open circle) (n = 12), femoral vein (full circle) (n = 7), external iliac vein (open square) (n = 9). The histamine-induced increases in tension are normalized for vessel cross-sectional area, and absolute values of the increase in tension are shown. Data represent mean ± S.E.M.
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fig01: Histamine-induced contraction in isolated rabbit vessels. Saphenous vein (open circle) (n = 12), femoral vein (full circle) (n = 7), external iliac vein (open square) (n = 9). The histamine-induced increases in tension are normalized for vessel cross-sectional area, and absolute values of the increase in tension are shown. Data represent mean ± S.E.M.

Mentions: Histamine (10 pM to 100 μM) evoked a concentration-dependent increase of contractile force, but Emax of E/[A] was significantly different in various types of veins. Veins have substantial histamine sensitivity in the lower (saphenous vein, femoral vein) and upper extremities (axillary vein), as well as in the abdomen (common iliac vein, inferior vena cava). In contrast, the thoracic veins (thoracic part of inferior vena cava, right and left superior vena cavas, subclavian vein) and one pelvic vein, external iliac vein were virtually insensitive to histamine (Figs 1–3 and Table 1).


Histamine and H1 -histamine receptors faster venous circulation.

Galajda Z, Balla J, Szentmiklosi AJ, Biro T, Czifra G, Dobrosi N, Cseppento A, Patonay L, Roszer T, Balla G, Popescu LM, Lekli I, Tosaki A - J. Cell. Mol. Med. (2011)

Histamine-induced contraction in isolated rabbit vessels. Saphenous vein (open circle) (n = 12), femoral vein (full circle) (n = 7), external iliac vein (open square) (n = 9). The histamine-induced increases in tension are normalized for vessel cross-sectional area, and absolute values of the increase in tension are shown. Data represent mean ± S.E.M.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4373430&req=5

fig01: Histamine-induced contraction in isolated rabbit vessels. Saphenous vein (open circle) (n = 12), femoral vein (full circle) (n = 7), external iliac vein (open square) (n = 9). The histamine-induced increases in tension are normalized for vessel cross-sectional area, and absolute values of the increase in tension are shown. Data represent mean ± S.E.M.
Mentions: Histamine (10 pM to 100 μM) evoked a concentration-dependent increase of contractile force, but Emax of E/[A] was significantly different in various types of veins. Veins have substantial histamine sensitivity in the lower (saphenous vein, femoral vein) and upper extremities (axillary vein), as well as in the abdomen (common iliac vein, inferior vena cava). In contrast, the thoracic veins (thoracic part of inferior vena cava, right and left superior vena cavas, subclavian vein) and one pelvic vein, external iliac vein were virtually insensitive to histamine (Figs 1–3 and Table 1).

Bottom Line: Voltage-dependent calcium channels mediated mainly the histamine-induced force generation of saphenous vein, whereas it did not act in the inferior vena cava.Furthermore, a significantly greater histamine immunopositivity was detected in veins after stretching compared to the resting state.We conclude that histamine receptor density adapts to the actual requirements of the circulation, and histamine liberated by the venous wall during increased venous pressure contributes to the contraction of vessels, providing a force for the venous return.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, Institute of Vascular Surgery, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary.

Show MeSH
Related in: MedlinePlus