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The primary cilium of telocytes in the vasculature: electron microscope imaging.

Cantarero I, Luesma MJ, Junquera C - J. Cell. Mol. Med. (2011)

Bottom Line: The fine structure of the wall of blood vessels has been studied previously using the electron microscope, but the presence the telocytes associated with vasculature, a specific new cellular entity, has not been studied in depth.Interestingly, telocytes have been recently found in the epicardium, myocardium, endocardium, human term placenta, duodenal lamina propria and pleura.Here, the telocyte-blood vessels cell proximity, the relationship between telocytes, exosomes and nervous trunks may have a special significance.

View Article: PubMed Central - PubMed

Affiliation: Department of Human Anatomy and Histology, Faculty of Medicine, University of Zaragoza, Zaragoza, Spain. irene-cantarero@hotmail.com

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Duodenal venule. (A) Telocyte located in parallel between the cells of the vessel wall and a nerve trunk. Note as the cytoplasm of telocyte establishes interactions with vascular smooth muscle. Black rectangular illustrating the primary cilium. (B) Longitudinally section. Some telocytes exhibit a primary cilium. The basal body resides at the base of the cilium-pit and is associated with its membrane via the distal appendages (white arrow). Below the distal appendages are the subdistal appendages (black arrow). smc: smooth muscle cells; tp: telopodes; nt: nervous trunk; TC: telocyte; e: endothelial cell; ve: venule; G: golgi apparatus; m: mitochondria; rer: rough endoplasmic reticulum; li: lipid drop.
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fig06: Duodenal venule. (A) Telocyte located in parallel between the cells of the vessel wall and a nerve trunk. Note as the cytoplasm of telocyte establishes interactions with vascular smooth muscle. Black rectangular illustrating the primary cilium. (B) Longitudinally section. Some telocytes exhibit a primary cilium. The basal body resides at the base of the cilium-pit and is associated with its membrane via the distal appendages (white arrow). Below the distal appendages are the subdistal appendages (black arrow). smc: smooth muscle cells; tp: telopodes; nt: nervous trunk; TC: telocyte; e: endothelial cell; ve: venule; G: golgi apparatus; m: mitochondria; rer: rough endoplasmic reticulum; li: lipid drop.

Mentions: Vascular telocytes showed typical features: small cellular body; long, thin and moniliform prolongations with dichotomic branching pattern; mitochondria, well-developed Golgi apparatus and polyribosomes. In addition, we have identified a novel cytoplasmic component; a deep invagination that is continuous with the plasma membrane, the cilium-pit, which accommodate the primary cilium (Fig. 5A and B). The cilium that extends into the extracellular matrix showed a structure 9 + 0 (absence of the central filaments) and a length of about 2–3 μm (Fig. 6A and B).


The primary cilium of telocytes in the vasculature: electron microscope imaging.

Cantarero I, Luesma MJ, Junquera C - J. Cell. Mol. Med. (2011)

Duodenal venule. (A) Telocyte located in parallel between the cells of the vessel wall and a nerve trunk. Note as the cytoplasm of telocyte establishes interactions with vascular smooth muscle. Black rectangular illustrating the primary cilium. (B) Longitudinally section. Some telocytes exhibit a primary cilium. The basal body resides at the base of the cilium-pit and is associated with its membrane via the distal appendages (white arrow). Below the distal appendages are the subdistal appendages (black arrow). smc: smooth muscle cells; tp: telopodes; nt: nervous trunk; TC: telocyte; e: endothelial cell; ve: venule; G: golgi apparatus; m: mitochondria; rer: rough endoplasmic reticulum; li: lipid drop.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4373428&req=5

fig06: Duodenal venule. (A) Telocyte located in parallel between the cells of the vessel wall and a nerve trunk. Note as the cytoplasm of telocyte establishes interactions with vascular smooth muscle. Black rectangular illustrating the primary cilium. (B) Longitudinally section. Some telocytes exhibit a primary cilium. The basal body resides at the base of the cilium-pit and is associated with its membrane via the distal appendages (white arrow). Below the distal appendages are the subdistal appendages (black arrow). smc: smooth muscle cells; tp: telopodes; nt: nervous trunk; TC: telocyte; e: endothelial cell; ve: venule; G: golgi apparatus; m: mitochondria; rer: rough endoplasmic reticulum; li: lipid drop.
Mentions: Vascular telocytes showed typical features: small cellular body; long, thin and moniliform prolongations with dichotomic branching pattern; mitochondria, well-developed Golgi apparatus and polyribosomes. In addition, we have identified a novel cytoplasmic component; a deep invagination that is continuous with the plasma membrane, the cilium-pit, which accommodate the primary cilium (Fig. 5A and B). The cilium that extends into the extracellular matrix showed a structure 9 + 0 (absence of the central filaments) and a length of about 2–3 μm (Fig. 6A and B).

Bottom Line: The fine structure of the wall of blood vessels has been studied previously using the electron microscope, but the presence the telocytes associated with vasculature, a specific new cellular entity, has not been studied in depth.Interestingly, telocytes have been recently found in the epicardium, myocardium, endocardium, human term placenta, duodenal lamina propria and pleura.Here, the telocyte-blood vessels cell proximity, the relationship between telocytes, exosomes and nervous trunks may have a special significance.

View Article: PubMed Central - PubMed

Affiliation: Department of Human Anatomy and Histology, Faculty of Medicine, University of Zaragoza, Zaragoza, Spain. irene-cantarero@hotmail.com

Show MeSH