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The primary cilium of telocytes in the vasculature: electron microscope imaging.

Cantarero I, Luesma MJ, Junquera C - J. Cell. Mol. Med. (2011)

Bottom Line: The fine structure of the wall of blood vessels has been studied previously using the electron microscope, but the presence the telocytes associated with vasculature, a specific new cellular entity, has not been studied in depth.Interestingly, telocytes have been recently found in the epicardium, myocardium, endocardium, human term placenta, duodenal lamina propria and pleura.Here, the telocyte-blood vessels cell proximity, the relationship between telocytes, exosomes and nervous trunks may have a special significance.

View Article: PubMed Central - PubMed

Affiliation: Department of Human Anatomy and Histology, Faculty of Medicine, University of Zaragoza, Zaragoza, Spain. irene-cantarero@hotmail.com

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Electron micrograph showing the close relationship between arteriole and telocytes. (A) Telocyte covering collagen and elastic fibres present in the tunica adventitia. (B and C) Higher magnification of boxed areas in A. (B) Gap junction connecting the processes of two telopodes. (C) Two dilatations, podoms (pd1 and pd2) which accommodate rough endoplasmic reticulum. ar: arteriole; smcs: smooth muscle cells; tp: telopodes; nt: nervous trunk; TC: telocyte; pd: podom.
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fig03: Electron micrograph showing the close relationship between arteriole and telocytes. (A) Telocyte covering collagen and elastic fibres present in the tunica adventitia. (B and C) Higher magnification of boxed areas in A. (B) Gap junction connecting the processes of two telopodes. (C) Two dilatations, podoms (pd1 and pd2) which accommodate rough endoplasmic reticulum. ar: arteriole; smcs: smooth muscle cells; tp: telopodes; nt: nervous trunk; TC: telocyte; pd: podom.

Mentions: Using electron microscopy, we observed that telocytes have been clearly found in the loose connective tissue surrounding the arterioles, venules and capillaries. Telocytes associated with the vasculature were morphologically similar to those previously found in other locations. In arterioles, the telocytes often send telopodes bordering the tunica adventitia (Fig. 3A). The adjacent telopodes may establish junctional complexes (Fig. 3B) and show small dilatations (podoms) that accommodate rough endoplasmic reticulum (Fig. 3C). In relation to venules and capillaries, the telocytes were located parallel with the longitudinal axis of the smooth muscle cells of the vessel wall (Fig. 4A and B, respectively). Also, the telopodes can form a wide network around the blood vessels (Fig. 4C).


The primary cilium of telocytes in the vasculature: electron microscope imaging.

Cantarero I, Luesma MJ, Junquera C - J. Cell. Mol. Med. (2011)

Electron micrograph showing the close relationship between arteriole and telocytes. (A) Telocyte covering collagen and elastic fibres present in the tunica adventitia. (B and C) Higher magnification of boxed areas in A. (B) Gap junction connecting the processes of two telopodes. (C) Two dilatations, podoms (pd1 and pd2) which accommodate rough endoplasmic reticulum. ar: arteriole; smcs: smooth muscle cells; tp: telopodes; nt: nervous trunk; TC: telocyte; pd: podom.
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Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4373428&req=5

fig03: Electron micrograph showing the close relationship between arteriole and telocytes. (A) Telocyte covering collagen and elastic fibres present in the tunica adventitia. (B and C) Higher magnification of boxed areas in A. (B) Gap junction connecting the processes of two telopodes. (C) Two dilatations, podoms (pd1 and pd2) which accommodate rough endoplasmic reticulum. ar: arteriole; smcs: smooth muscle cells; tp: telopodes; nt: nervous trunk; TC: telocyte; pd: podom.
Mentions: Using electron microscopy, we observed that telocytes have been clearly found in the loose connective tissue surrounding the arterioles, venules and capillaries. Telocytes associated with the vasculature were morphologically similar to those previously found in other locations. In arterioles, the telocytes often send telopodes bordering the tunica adventitia (Fig. 3A). The adjacent telopodes may establish junctional complexes (Fig. 3B) and show small dilatations (podoms) that accommodate rough endoplasmic reticulum (Fig. 3C). In relation to venules and capillaries, the telocytes were located parallel with the longitudinal axis of the smooth muscle cells of the vessel wall (Fig. 4A and B, respectively). Also, the telopodes can form a wide network around the blood vessels (Fig. 4C).

Bottom Line: The fine structure of the wall of blood vessels has been studied previously using the electron microscope, but the presence the telocytes associated with vasculature, a specific new cellular entity, has not been studied in depth.Interestingly, telocytes have been recently found in the epicardium, myocardium, endocardium, human term placenta, duodenal lamina propria and pleura.Here, the telocyte-blood vessels cell proximity, the relationship between telocytes, exosomes and nervous trunks may have a special significance.

View Article: PubMed Central - PubMed

Affiliation: Department of Human Anatomy and Histology, Faculty of Medicine, University of Zaragoza, Zaragoza, Spain. irene-cantarero@hotmail.com

Show MeSH
Related in: MedlinePlus