Adipose-derived stem cells accelerate neovascularization in ischaemic diabetic skin flap via expression of hypoxia-inducible factor-1α.
Bottom Line: Skin flaps are frequently performed for diabetic patients in spite of countless detrimental effects of diabetes on flap survival, most of which may result from a defective response of the tissues to low oxygen tension.The flap survival rate of group A was significantly higher than those of groups B and C, whereas no difference was observed between groups B and C.Histological examination also demonstrated a statistically significant increase in capillary density in group A over both groups B and C.
Affiliation: Department of Plastic Surgery, 1st Teaching Hospital of Xinjiang Medical University, China.Show MeSH
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Mentions: To determine whether transplanted ASCs incorporated into vessels wall, by which angiogenesis was enhanced, we pre-labelled cells with fluorescent CM-Dii before transplantation. The distribution of labelled cells was observed on day 7 (Fig. 3). The survival of transplanted ASCs was demonstrated by the presence of labelled cells, most of which localized subcutaneously in a pattern of aggregation close to vasculature. However, little labelled cells could be detected in the wall of blood vessels.
Affiliation: Department of Plastic Surgery, 1st Teaching Hospital of Xinjiang Medical University, China.