Adipose-derived stem cells accelerate neovascularization in ischaemic diabetic skin flap via expression of hypoxia-inducible factor-1α.
Bottom Line: Skin flaps are frequently performed for diabetic patients in spite of countless detrimental effects of diabetes on flap survival, most of which may result from a defective response of the tissues to low oxygen tension.The flap survival rate of group A was significantly higher than those of groups B and C, whereas no difference was observed between groups B and C.Histological examination also demonstrated a statistically significant increase in capillary density in group A over both groups B and C.
Affiliation: Department of Plastic Surgery, 1st Teaching Hospital of Xinjiang Medical University, China.Show MeSH
Related in: MedlinePlus
Mentions: The surviving area in the flap was clearly distinguishable from necrotic one at day 7 post-operation in each group (Fig. 1A). By quantitative digital analysis, the mean proportion of flap viability in group A (ASCs transplantation group), group B (culture medium injection group) and group C (control group) was 83.2 ± 5.3%, 47.0 ± 10.5% and 43.7 ± 4.5%, respectively (Fig. 1B). The surviving area in group A was significantly higher than that either in group B (P < 0.01) or in group C (P < 0.01). However, no significant difference was found between group B and group C (P > 0.05).
Affiliation: Department of Plastic Surgery, 1st Teaching Hospital of Xinjiang Medical University, China.