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Long-term restricted feeding alters circadian expression and reduces the level of inflammatory and disease markers.

Sherman H, Frumin I, Gutman R, Chapnik N, Lorentz A, Meylan J, le Coutre J, Froy O - J. Cell. Mol. Med. (2011)

Bottom Line: However, it is not known whether RF can delay the occurrence of age-associated changes similar to CR.We found that circadian rhythmicity is more robust and is phase advanced in most of the genes and proteins tested under RF.Our results suggest that RF may share some benefits with those of CR.

View Article: PubMed Central - PubMed

Affiliation: Institute of Biochemistry, Food Science and Nutrition, Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel.

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Circadian rhythms and average mRNA levels of inflammation markers in the liver, jejunum and WAT of AL- and RF-fed mice. Liver, jejunum and WAT were collected every 3 hrs around the circadian cycle from mice fed either AL (solid black line and columns) or RF (dashed grey lined and grey columns). Food availability during RF is marked by the crosshatched box. mRNA was quantified by real-time PCR. Inflammation gene levels were normalized using Gapdh as the reference gene. For total daily levels, all time-points were averaged. The grey and black bars designate the subjective day and night, respectively. Values are means ± S.E., n = 6 for each time-point in each group. Asterisk denotes significant difference (P < 0.05).
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fig07: Circadian rhythms and average mRNA levels of inflammation markers in the liver, jejunum and WAT of AL- and RF-fed mice. Liver, jejunum and WAT were collected every 3 hrs around the circadian cycle from mice fed either AL (solid black line and columns) or RF (dashed grey lined and grey columns). Food availability during RF is marked by the crosshatched box. mRNA was quantified by real-time PCR. Inflammation gene levels were normalized using Gapdh as the reference gene. For total daily levels, all time-points were averaged. The grey and black bars designate the subjective day and night, respectively. Values are means ± S.E., n = 6 for each time-point in each group. Asterisk denotes significant difference (P < 0.05).

Mentions: Crp oscillated under AL and RF in the jejunum (P < 0.001, one-way anova) and WAT (P < 0.0001, one-way anova) (Fig. 7; Table S2). WAT Crp amplitude increased substantially under RF during the subjective night but without a rise in total daily levels, suggesting a better adaptation to activity–rest immune function. Crp mRNA daily average levels were significantly up-regulated (1.3-fold, P < 0.05, Student’s t-test) in the liver, with no change in the jejunum and WAT (Fig. 7; Table S4) or serum protein levels (Fig. 5; Table S4).


Long-term restricted feeding alters circadian expression and reduces the level of inflammatory and disease markers.

Sherman H, Frumin I, Gutman R, Chapnik N, Lorentz A, Meylan J, le Coutre J, Froy O - J. Cell. Mol. Med. (2011)

Circadian rhythms and average mRNA levels of inflammation markers in the liver, jejunum and WAT of AL- and RF-fed mice. Liver, jejunum and WAT were collected every 3 hrs around the circadian cycle from mice fed either AL (solid black line and columns) or RF (dashed grey lined and grey columns). Food availability during RF is marked by the crosshatched box. mRNA was quantified by real-time PCR. Inflammation gene levels were normalized using Gapdh as the reference gene. For total daily levels, all time-points were averaged. The grey and black bars designate the subjective day and night, respectively. Values are means ± S.E., n = 6 for each time-point in each group. Asterisk denotes significant difference (P < 0.05).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4373423&req=5

fig07: Circadian rhythms and average mRNA levels of inflammation markers in the liver, jejunum and WAT of AL- and RF-fed mice. Liver, jejunum and WAT were collected every 3 hrs around the circadian cycle from mice fed either AL (solid black line and columns) or RF (dashed grey lined and grey columns). Food availability during RF is marked by the crosshatched box. mRNA was quantified by real-time PCR. Inflammation gene levels were normalized using Gapdh as the reference gene. For total daily levels, all time-points were averaged. The grey and black bars designate the subjective day and night, respectively. Values are means ± S.E., n = 6 for each time-point in each group. Asterisk denotes significant difference (P < 0.05).
Mentions: Crp oscillated under AL and RF in the jejunum (P < 0.001, one-way anova) and WAT (P < 0.0001, one-way anova) (Fig. 7; Table S2). WAT Crp amplitude increased substantially under RF during the subjective night but without a rise in total daily levels, suggesting a better adaptation to activity–rest immune function. Crp mRNA daily average levels were significantly up-regulated (1.3-fold, P < 0.05, Student’s t-test) in the liver, with no change in the jejunum and WAT (Fig. 7; Table S4) or serum protein levels (Fig. 5; Table S4).

Bottom Line: However, it is not known whether RF can delay the occurrence of age-associated changes similar to CR.We found that circadian rhythmicity is more robust and is phase advanced in most of the genes and proteins tested under RF.Our results suggest that RF may share some benefits with those of CR.

View Article: PubMed Central - PubMed

Affiliation: Institute of Biochemistry, Food Science and Nutrition, Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel.

Show MeSH
Related in: MedlinePlus