Keeping track of the growing number of biological functions of chitin and its interaction partners in biomedical research.
Bottom Line: In many studies, these proteins have been found to be involved in immune regulation and in mediating the degradation of chitinous external protective structures of invading pathogens.Finally, we examine the existing literature on zebrafish chitinases, and propose the use of zebrafish as a versatile model to complement the existing murine models.This could especially be of benefit to the exploration of the function of chitinases in infectious diseases using high-throughput approaches and pharmaceutical interventions.
Affiliation: Department of Molecular Biology and Genetics, Aarhus University, Aarhus C, Denmark Leiden University, Institute of Biology, Leiden, The Netherlands.Show MeSH
Related in: MedlinePlus
Mentions: When considering the literature as a whole, it is clear that the overall outcome of chitin particle stimulation in terms of inflammatory responses, cellular migration and macrophage activation, is subject to different influences deriving from different cell-types, and observing only one of these factors will lead to confusion and misinterpretations. Figure 2 provides a summary of the observed immune responses to different chitin particles in different tissues.Fig. 2.
Affiliation: Department of Molecular Biology and Genetics, Aarhus University, Aarhus C, Denmark Leiden University, Institute of Biology, Leiden, The Netherlands.