Circulating stem cell vary with NYHA stage in heart failure patients.
Bottom Line: Compared with healthy individuals, MSC, and in particular the sub-classes CD45(-) CD34(-) CD90(+) , CD45(-) CD34(-) CD105(+) and CD45(-) CD34(-) CXCR4(+) were significantly enhanced in NYHA class IV patients (16.8-, 6.4- and 2.7-fold, respectively).Level of CD45(-) CD34(-) CD90(+) CXCR4(+) cells progressively increased from class II to class IV (fold increases compared with controls: 8.5, 12 and 21.5, respectively).Both the entity and kinetic of this process varied in distinct cell subsets.
Affiliation: University of Ferrara and Cardiovascular Research Center, Salvatore Maugeri Foundation, IRCCS, Lumezzane, Italy. firstname.lastname@example.orgShow MeSH
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Mentions: Figure 6 shows the plasma behaviours of all the measured cytokines. PDGF-BB, TNF-α and SDF-1α (Fig. 6A, E and F) show a significant progressive increase with the deterioration of HF (P < 0.0001, P = 0.0004 and P < 0.0001, respectively). HGF and bFGF (Fig. 6B and C) are also significantly raised but do not show a progressive increase. VEGF is significantly elevated in NYHA I, but not in the more advanced ones (Fig. 6D).
Affiliation: University of Ferrara and Cardiovascular Research Center, Salvatore Maugeri Foundation, IRCCS, Lumezzane, Italy. email@example.com