Circulating stem cell vary with NYHA stage in heart failure patients.
Bottom Line: Level of CD45(-) CD34(-) CD90(+) CXCR4(+) cells progressively increased from class II to class IV (fold increases compared with controls: 8.5, 12 and 21.5, respectively).Both the entity and kinetic of this process varied in distinct cell subsets.Specifically, differently from HSCs and EPCs/CECs, MSCs and TCSCs significantly increased with the progression of the disease, suggesting a possible distinct role of these cells in the pathophysiology of HF.
Affiliation: University of Ferrara and Cardiovascular Research Center, Salvatore Maugeri Foundation, IRCCS, Lumezzane, Italy. email@example.comShow MeSH
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Mentions: Figure 6 shows the plasma behaviours of all the measured cytokines. PDGF-BB, TNF-α and SDF-1α (Fig. 6A, E and F) show a significant progressive increase with the deterioration of HF (P < 0.0001, P = 0.0004 and P < 0.0001, respectively). HGF and bFGF (Fig. 6B and C) are also significantly raised but do not show a progressive increase. VEGF is significantly elevated in NYHA I, but not in the more advanced ones (Fig. 6D).
Affiliation: University of Ferrara and Cardiovascular Research Center, Salvatore Maugeri Foundation, IRCCS, Lumezzane, Italy. firstname.lastname@example.org