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Circulating stem cell vary with NYHA stage in heart failure patients.

Fortini C, Toffoletto B, Fucili A, Puppato E, Olivares A, Beltrami AP, Fiorelli V, Bergamin N, Cesselli D, Morelli C, Francolini G, Ferrari R, Beltrami CA - J. Cell. Mol. Med. (2011)

Bottom Line: Level of CD45(-) CD34(-) CD90(+) CXCR4(+) cells progressively increased from class II to class IV (fold increases compared with controls: 8.5, 12 and 21.5, respectively).Both the entity and kinetic of this process varied in distinct cell subsets.Specifically, differently from HSCs and EPCs/CECs, MSCs and TCSCs significantly increased with the progression of the disease, suggesting a possible distinct role of these cells in the pathophysiology of HF.

View Article: PubMed Central - PubMed

Affiliation: University of Ferrara and Cardiovascular Research Center, Salvatore Maugeri Foundation, IRCCS, Lumezzane, Italy. cfortini@mtagroup.net

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Cytokines plasmatic level in HF patients. Histograms represent plasma concentration of PDGF-BB (A), HGF (B), bFGF (C), VEGF (D), TNF-α (E) and SDF-1α (F) in healthy individuals and HF patients. Significative difference between controls and patients are reported as P value. Data are expressed as mean ± S.D.
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fig06: Cytokines plasmatic level in HF patients. Histograms represent plasma concentration of PDGF-BB (A), HGF (B), bFGF (C), VEGF (D), TNF-α (E) and SDF-1α (F) in healthy individuals and HF patients. Significative difference between controls and patients are reported as P value. Data are expressed as mean ± S.D.

Mentions: Figure 6 shows the plasma behaviours of all the measured cytokines. PDGF-BB, TNF-α and SDF-1α (Fig. 6A, E and F) show a significant progressive increase with the deterioration of HF (P < 0.0001, P = 0.0004 and P < 0.0001, respectively). HGF and bFGF (Fig. 6B and C) are also significantly raised but do not show a progressive increase. VEGF is significantly elevated in NYHA I, but not in the more advanced ones (Fig. 6D).


Circulating stem cell vary with NYHA stage in heart failure patients.

Fortini C, Toffoletto B, Fucili A, Puppato E, Olivares A, Beltrami AP, Fiorelli V, Bergamin N, Cesselli D, Morelli C, Francolini G, Ferrari R, Beltrami CA - J. Cell. Mol. Med. (2011)

Cytokines plasmatic level in HF patients. Histograms represent plasma concentration of PDGF-BB (A), HGF (B), bFGF (C), VEGF (D), TNF-α (E) and SDF-1α (F) in healthy individuals and HF patients. Significative difference between controls and patients are reported as P value. Data are expressed as mean ± S.D.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4373363&req=5

fig06: Cytokines plasmatic level in HF patients. Histograms represent plasma concentration of PDGF-BB (A), HGF (B), bFGF (C), VEGF (D), TNF-α (E) and SDF-1α (F) in healthy individuals and HF patients. Significative difference between controls and patients are reported as P value. Data are expressed as mean ± S.D.
Mentions: Figure 6 shows the plasma behaviours of all the measured cytokines. PDGF-BB, TNF-α and SDF-1α (Fig. 6A, E and F) show a significant progressive increase with the deterioration of HF (P < 0.0001, P = 0.0004 and P < 0.0001, respectively). HGF and bFGF (Fig. 6B and C) are also significantly raised but do not show a progressive increase. VEGF is significantly elevated in NYHA I, but not in the more advanced ones (Fig. 6D).

Bottom Line: Level of CD45(-) CD34(-) CD90(+) CXCR4(+) cells progressively increased from class II to class IV (fold increases compared with controls: 8.5, 12 and 21.5, respectively).Both the entity and kinetic of this process varied in distinct cell subsets.Specifically, differently from HSCs and EPCs/CECs, MSCs and TCSCs significantly increased with the progression of the disease, suggesting a possible distinct role of these cells in the pathophysiology of HF.

View Article: PubMed Central - PubMed

Affiliation: University of Ferrara and Cardiovascular Research Center, Salvatore Maugeri Foundation, IRCCS, Lumezzane, Italy. cfortini@mtagroup.net

Show MeSH
Related in: MedlinePlus