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Circulating stem cell vary with NYHA stage in heart failure patients.

Fortini C, Toffoletto B, Fucili A, Puppato E, Olivares A, Beltrami AP, Fiorelli V, Bergamin N, Cesselli D, Morelli C, Francolini G, Ferrari R, Beltrami CA - J. Cell. Mol. Med. (2011)

Bottom Line: Level of CD45(-) CD34(-) CD90(+) CXCR4(+) cells progressively increased from class II to class IV (fold increases compared with controls: 8.5, 12 and 21.5, respectively).Both the entity and kinetic of this process varied in distinct cell subsets.Specifically, differently from HSCs and EPCs/CECs, MSCs and TCSCs significantly increased with the progression of the disease, suggesting a possible distinct role of these cells in the pathophysiology of HF.

View Article: PubMed Central - PubMed

Affiliation: University of Ferrara and Cardiovascular Research Center, Salvatore Maugeri Foundation, IRCCS, Lumezzane, Italy. cfortini@mtagroup.net

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Circulating tissue committed stem cells in HF patients. Specific subset (CD45− and CD45+ and CD45−PDGFR+) of CD34+CXCR4+ SCs are analysed. Significative difference are found between all patients and controls in all populations. Differences in specific NYHA classes was found in CD45−CD34+CXCR4+ (B), but not in CD45−CD34+CXCR4+ (A) and in PDGFR-positive (C) cells. Significative difference between controls and patients are reported as P value. Data are expressed as mean ± S.D.
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fig05: Circulating tissue committed stem cells in HF patients. Specific subset (CD45− and CD45+ and CD45−PDGFR+) of CD34+CXCR4+ SCs are analysed. Significative difference are found between all patients and controls in all populations. Differences in specific NYHA classes was found in CD45−CD34+CXCR4+ (B), but not in CD45−CD34+CXCR4+ (A) and in PDGFR-positive (C) cells. Significative difference between controls and patients are reported as P value. Data are expressed as mean ± S.D.

Mentions: The results obtained for each class of stem cells are reported in Figures 2 (MSC), 3 (HSC), 4 (EPC/CEC) and 5 (TCSC), respectively.


Circulating stem cell vary with NYHA stage in heart failure patients.

Fortini C, Toffoletto B, Fucili A, Puppato E, Olivares A, Beltrami AP, Fiorelli V, Bergamin N, Cesselli D, Morelli C, Francolini G, Ferrari R, Beltrami CA - J. Cell. Mol. Med. (2011)

Circulating tissue committed stem cells in HF patients. Specific subset (CD45− and CD45+ and CD45−PDGFR+) of CD34+CXCR4+ SCs are analysed. Significative difference are found between all patients and controls in all populations. Differences in specific NYHA classes was found in CD45−CD34+CXCR4+ (B), but not in CD45−CD34+CXCR4+ (A) and in PDGFR-positive (C) cells. Significative difference between controls and patients are reported as P value. Data are expressed as mean ± S.D.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4373363&req=5

fig05: Circulating tissue committed stem cells in HF patients. Specific subset (CD45− and CD45+ and CD45−PDGFR+) of CD34+CXCR4+ SCs are analysed. Significative difference are found between all patients and controls in all populations. Differences in specific NYHA classes was found in CD45−CD34+CXCR4+ (B), but not in CD45−CD34+CXCR4+ (A) and in PDGFR-positive (C) cells. Significative difference between controls and patients are reported as P value. Data are expressed as mean ± S.D.
Mentions: The results obtained for each class of stem cells are reported in Figures 2 (MSC), 3 (HSC), 4 (EPC/CEC) and 5 (TCSC), respectively.

Bottom Line: Level of CD45(-) CD34(-) CD90(+) CXCR4(+) cells progressively increased from class II to class IV (fold increases compared with controls: 8.5, 12 and 21.5, respectively).Both the entity and kinetic of this process varied in distinct cell subsets.Specifically, differently from HSCs and EPCs/CECs, MSCs and TCSCs significantly increased with the progression of the disease, suggesting a possible distinct role of these cells in the pathophysiology of HF.

View Article: PubMed Central - PubMed

Affiliation: University of Ferrara and Cardiovascular Research Center, Salvatore Maugeri Foundation, IRCCS, Lumezzane, Italy. cfortini@mtagroup.net

Show MeSH
Related in: MedlinePlus