Circulating stem cell vary with NYHA stage in heart failure patients.
Bottom Line: Compared with healthy individuals, MSC, and in particular the sub-classes CD45(-) CD34(-) CD90(+) , CD45(-) CD34(-) CD105(+) and CD45(-) CD34(-) CXCR4(+) were significantly enhanced in NYHA class IV patients (16.8-, 6.4- and 2.7-fold, respectively).Level of CD45(-) CD34(-) CD90(+) CXCR4(+) cells progressively increased from class II to class IV (fold increases compared with controls: 8.5, 12 and 21.5, respectively).Both the entity and kinetic of this process varied in distinct cell subsets.
Affiliation: University of Ferrara and Cardiovascular Research Center, Salvatore Maugeri Foundation, IRCCS, Lumezzane, Italy. firstname.lastname@example.orgShow MeSH
Related in: MedlinePlus
Mentions: Figure 4 shows the behaviour of the EPC fractions. Mean values in patients were significantly increased versus controls. The behaviour of TCSCs is reported in Figure 5. Interestingly, the CD45−CD34+CXCR4+ cells, which are committed to myocytes and endothelium, show a significant trend to increase with the severity of HF (P < 0.0001), similarly to the MSCs (Fig. 5B). Conversely, the CD45+CD34+CXCR4+ cells (Fig. 5A), which are committed to form lymphocytes and monocytes, although showing a significant increase in patient with respect to controls, did not present such a significative progressive raise.
Affiliation: University of Ferrara and Cardiovascular Research Center, Salvatore Maugeri Foundation, IRCCS, Lumezzane, Italy. email@example.com