Circulating stem cell vary with NYHA stage in heart failure patients.
Bottom Line: Level of CD45(-) CD34(-) CD90(+) CXCR4(+) cells progressively increased from class II to class IV (fold increases compared with controls: 8.5, 12 and 21.5, respectively).Both the entity and kinetic of this process varied in distinct cell subsets.Specifically, differently from HSCs and EPCs/CECs, MSCs and TCSCs significantly increased with the progression of the disease, suggesting a possible distinct role of these cells in the pathophysiology of HF.
Affiliation: University of Ferrara and Cardiovascular Research Center, Salvatore Maugeri Foundation, IRCCS, Lumezzane, Italy. firstname.lastname@example.orgShow MeSH
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Mentions: Figure 4 shows the behaviour of the EPC fractions. Mean values in patients were significantly increased versus controls. The behaviour of TCSCs is reported in Figure 5. Interestingly, the CD45−CD34+CXCR4+ cells, which are committed to myocytes and endothelium, show a significant trend to increase with the severity of HF (P < 0.0001), similarly to the MSCs (Fig. 5B). Conversely, the CD45+CD34+CXCR4+ cells (Fig. 5A), which are committed to form lymphocytes and monocytes, although showing a significant increase in patient with respect to controls, did not present such a significative progressive raise.
Affiliation: University of Ferrara and Cardiovascular Research Center, Salvatore Maugeri Foundation, IRCCS, Lumezzane, Italy. email@example.com