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Circulating stem cell vary with NYHA stage in heart failure patients.

Fortini C, Toffoletto B, Fucili A, Puppato E, Olivares A, Beltrami AP, Fiorelli V, Bergamin N, Cesselli D, Morelli C, Francolini G, Ferrari R, Beltrami CA - J. Cell. Mol. Med. (2011)

Bottom Line: Level of CD45(-) CD34(-) CD90(+) CXCR4(+) cells progressively increased from class II to class IV (fold increases compared with controls: 8.5, 12 and 21.5, respectively).Both the entity and kinetic of this process varied in distinct cell subsets.Specifically, differently from HSCs and EPCs/CECs, MSCs and TCSCs significantly increased with the progression of the disease, suggesting a possible distinct role of these cells in the pathophysiology of HF.

View Article: PubMed Central - PubMed

Affiliation: University of Ferrara and Cardiovascular Research Center, Salvatore Maugeri Foundation, IRCCS, Lumezzane, Italy. cfortini@mtagroup.net

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Circulating endothelial precursors/cells in HF patients. Differences in EPCs/ECs level between all patients and control is significative. Number of cells, compared with controls, is higher in I–III NYHA classes and decreases in IV NYHA class, even if differences are not significative in any tested point. (A) Endothelial precursors cells; (B) differentiating endothelial cells; (C) mature endothelial cells. Data are expressed as mean ± S.D.
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fig04: Circulating endothelial precursors/cells in HF patients. Differences in EPCs/ECs level between all patients and control is significative. Number of cells, compared with controls, is higher in I–III NYHA classes and decreases in IV NYHA class, even if differences are not significative in any tested point. (A) Endothelial precursors cells; (B) differentiating endothelial cells; (C) mature endothelial cells. Data are expressed as mean ± S.D.

Mentions: Figure 4 shows the behaviour of the EPC fractions. Mean values in patients were significantly increased versus controls. The behaviour of TCSCs is reported in Figure 5. Interestingly, the CD45−CD34+CXCR4+ cells, which are committed to myocytes and endothelium, show a significant trend to increase with the severity of HF (P < 0.0001), similarly to the MSCs (Fig. 5B). Conversely, the CD45+CD34+CXCR4+ cells (Fig. 5A), which are committed to form lymphocytes and monocytes, although showing a significant increase in patient with respect to controls, did not present such a significative progressive raise.


Circulating stem cell vary with NYHA stage in heart failure patients.

Fortini C, Toffoletto B, Fucili A, Puppato E, Olivares A, Beltrami AP, Fiorelli V, Bergamin N, Cesselli D, Morelli C, Francolini G, Ferrari R, Beltrami CA - J. Cell. Mol. Med. (2011)

Circulating endothelial precursors/cells in HF patients. Differences in EPCs/ECs level between all patients and control is significative. Number of cells, compared with controls, is higher in I–III NYHA classes and decreases in IV NYHA class, even if differences are not significative in any tested point. (A) Endothelial precursors cells; (B) differentiating endothelial cells; (C) mature endothelial cells. Data are expressed as mean ± S.D.
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Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4373363&req=5

fig04: Circulating endothelial precursors/cells in HF patients. Differences in EPCs/ECs level between all patients and control is significative. Number of cells, compared with controls, is higher in I–III NYHA classes and decreases in IV NYHA class, even if differences are not significative in any tested point. (A) Endothelial precursors cells; (B) differentiating endothelial cells; (C) mature endothelial cells. Data are expressed as mean ± S.D.
Mentions: Figure 4 shows the behaviour of the EPC fractions. Mean values in patients were significantly increased versus controls. The behaviour of TCSCs is reported in Figure 5. Interestingly, the CD45−CD34+CXCR4+ cells, which are committed to myocytes and endothelium, show a significant trend to increase with the severity of HF (P < 0.0001), similarly to the MSCs (Fig. 5B). Conversely, the CD45+CD34+CXCR4+ cells (Fig. 5A), which are committed to form lymphocytes and monocytes, although showing a significant increase in patient with respect to controls, did not present such a significative progressive raise.

Bottom Line: Level of CD45(-) CD34(-) CD90(+) CXCR4(+) cells progressively increased from class II to class IV (fold increases compared with controls: 8.5, 12 and 21.5, respectively).Both the entity and kinetic of this process varied in distinct cell subsets.Specifically, differently from HSCs and EPCs/CECs, MSCs and TCSCs significantly increased with the progression of the disease, suggesting a possible distinct role of these cells in the pathophysiology of HF.

View Article: PubMed Central - PubMed

Affiliation: University of Ferrara and Cardiovascular Research Center, Salvatore Maugeri Foundation, IRCCS, Lumezzane, Italy. cfortini@mtagroup.net

Show MeSH
Related in: MedlinePlus