Circulating stem cell vary with NYHA stage in heart failure patients.
Bottom Line: Level of CD45(-) CD34(-) CD90(+) CXCR4(+) cells progressively increased from class II to class IV (fold increases compared with controls: 8.5, 12 and 21.5, respectively).Both the entity and kinetic of this process varied in distinct cell subsets.Specifically, differently from HSCs and EPCs/CECs, MSCs and TCSCs significantly increased with the progression of the disease, suggesting a possible distinct role of these cells in the pathophysiology of HF.
Affiliation: University of Ferrara and Cardiovascular Research Center, Salvatore Maugeri Foundation, IRCCS, Lumezzane, Italy. email@example.comShow MeSH
Related in: MedlinePlus
Mentions: Conversely, HSCs (Fig. 3), although significantly augmented in patients with respect to controls, did not show a significant trend to increase with NYHA class. Emblematically, the fraction characterized as CD45+CD34+CD90+ expressing the CXCR4 receptor (Fig. 3C), peaks in class III patients and returns to control level in class IV. CD45+CD34+CD105+ cells expressing the CXCR4 and CD45+CD34+ cells expressing PDGFR were also increased in patients (Fig. 3D and E).
Affiliation: University of Ferrara and Cardiovascular Research Center, Salvatore Maugeri Foundation, IRCCS, Lumezzane, Italy. firstname.lastname@example.org