Nicotinamide-rich diet improves physical endurance by up-regulating SUR2A in the heart.
Bottom Line: We have found that mice on nicotinamide-rich diet significantly improved physical endurance, which was associated with significant increase in expression of SUR2A.The experiments focused on action membrane potential and intracellular Ca(2+) concentration have demonstrated that increased SUR2A expression was associated with the activation of sarcolemmal K(ATP) channels and steady Ca(2+) levels in cardiomyocytes in response to β-adrenergic stimulation.The obtained results suggest that oral nicotinamide is a regulator of SUR2A expression and has a potential as a drug that can improve physical endurance in conditions where this effect would be desirable.
Affiliation: Division of Medical Sciences, Centre for Cardiovascular and Lung Biology, Ninewells Hospital & Medical School, University of Dundee, Dundee, UK.Show MeSH
Mentions: To test physical endurance of mice on control and nicotinamide-rich diet, we have used treadmill as described previously . The tolerated workload, a parameter that incorporates time of effort with speed and incline of the treadmill, was significantly higher in mice on nicotinamide-rich diet compared with the mice on control diet (tolerated workload was 54.7 ± 5.1 J in mice on control and 104 ± 8.2 J in mice on nicotinamide-rich diet, n = 6 for each, P < 0.01; Fig. 3). Mice on control diet were able to stay on treadmill for 67.3 ± 6.2 min. (n = 6), while this time was significantly increased in mice on nicotinamide-rich diet (to 144.0 ± 14.9 min.; Fig. 3; P < 0.01).
Affiliation: Division of Medical Sciences, Centre for Cardiovascular and Lung Biology, Ninewells Hospital & Medical School, University of Dundee, Dundee, UK.