Inhibition of cardiac leptin expression after infarction reduces subsequent dysfunction.
Bottom Line: Our results show that (1) cardiac leptin level peaks 7 days after reperfused MI; (2) intramyocardial injection of leptin-AS ODN reduces early IL-1β and IL-6 overexpression and markedly protects contractile function.In conclusion, our findings demonstrate that cardiac leptin expression after MI could contribute to the evolution towards heart failure through autocrine and/or paracrine actions.The detrimental effect of leptin could be mediated by pro-inflammatory cytokines such as IL-1β and IL-6.
Affiliation: Laboratoire TIMC-IMAG, UMR 5525 CNRS - University of Grenoble, Grenoble, France.Show MeSH
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Mentions: Myocardial leptin, measured by ELISA, was significantly reduced 7 days after the initial surgical protocol in AS ODN-Treated rats compared to Control ODN-treated rats (Fig. 3A). Myocardial IL-1β (Fig. 3B) and IL-6 (Fig. 3C), measured by ELISA, were markedly reduced 7 days after reperfused infarction in the AS ODN-treated group compared to the Control ODN-treated group.
Affiliation: Laboratoire TIMC-IMAG, UMR 5525 CNRS - University of Grenoble, Grenoble, France.