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Inhibition of cardiac leptin expression after infarction reduces subsequent dysfunction.

Moro C, Grauzam S, Ormezzano O, Toufektsian MC, Tanguy S, Calabrese P, Coll JL, Bak I, Juhasz B, Tosaki A, de Leiris J, Boucher F - J. Cell. Mol. Med. (2011)

Bottom Line: Our results show that (1) cardiac leptin level peaks 7 days after reperfused MI; (2) intramyocardial injection of leptin-AS ODN reduces early IL-1β and IL-6 overexpression and markedly protects contractile function.In conclusion, our findings demonstrate that cardiac leptin expression after MI could contribute to the evolution towards heart failure through autocrine and/or paracrine actions.The detrimental effect of leptin could be mediated by pro-inflammatory cytokines such as IL-1β and IL-6.

View Article: PubMed Central - PubMed

Affiliation: Laboratoire TIMC-IMAG, UMR 5525 CNRS - University of Grenoble, Grenoble, France.

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Effect of antisense leptin inhibition on leptin, IL-1β and IL-6 myocardial levels, 7 days after reperfused MI. Leptin (A), IL-1β (B) and IL-6 (C) ELISA assays on six to seven hearts per group. Open bars: Control ODN-treated group; Full bars: AS ODN-treated group. Means ± S.E.M. *P < 0.05 versus Control ODN-treated group.
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fig03: Effect of antisense leptin inhibition on leptin, IL-1β and IL-6 myocardial levels, 7 days after reperfused MI. Leptin (A), IL-1β (B) and IL-6 (C) ELISA assays on six to seven hearts per group. Open bars: Control ODN-treated group; Full bars: AS ODN-treated group. Means ± S.E.M. *P < 0.05 versus Control ODN-treated group.

Mentions: Myocardial leptin, measured by ELISA, was significantly reduced 7 days after the initial surgical protocol in AS ODN-Treated rats compared to Control ODN-treated rats (Fig. 3A). Myocardial IL-1β (Fig. 3B) and IL-6 (Fig. 3C), measured by ELISA, were markedly reduced 7 days after reperfused infarction in the AS ODN-treated group compared to the Control ODN-treated group.


Inhibition of cardiac leptin expression after infarction reduces subsequent dysfunction.

Moro C, Grauzam S, Ormezzano O, Toufektsian MC, Tanguy S, Calabrese P, Coll JL, Bak I, Juhasz B, Tosaki A, de Leiris J, Boucher F - J. Cell. Mol. Med. (2011)

Effect of antisense leptin inhibition on leptin, IL-1β and IL-6 myocardial levels, 7 days after reperfused MI. Leptin (A), IL-1β (B) and IL-6 (C) ELISA assays on six to seven hearts per group. Open bars: Control ODN-treated group; Full bars: AS ODN-treated group. Means ± S.E.M. *P < 0.05 versus Control ODN-treated group.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4373359&req=5

fig03: Effect of antisense leptin inhibition on leptin, IL-1β and IL-6 myocardial levels, 7 days after reperfused MI. Leptin (A), IL-1β (B) and IL-6 (C) ELISA assays on six to seven hearts per group. Open bars: Control ODN-treated group; Full bars: AS ODN-treated group. Means ± S.E.M. *P < 0.05 versus Control ODN-treated group.
Mentions: Myocardial leptin, measured by ELISA, was significantly reduced 7 days after the initial surgical protocol in AS ODN-Treated rats compared to Control ODN-treated rats (Fig. 3A). Myocardial IL-1β (Fig. 3B) and IL-6 (Fig. 3C), measured by ELISA, were markedly reduced 7 days after reperfused infarction in the AS ODN-treated group compared to the Control ODN-treated group.

Bottom Line: Our results show that (1) cardiac leptin level peaks 7 days after reperfused MI; (2) intramyocardial injection of leptin-AS ODN reduces early IL-1β and IL-6 overexpression and markedly protects contractile function.In conclusion, our findings demonstrate that cardiac leptin expression after MI could contribute to the evolution towards heart failure through autocrine and/or paracrine actions.The detrimental effect of leptin could be mediated by pro-inflammatory cytokines such as IL-1β and IL-6.

View Article: PubMed Central - PubMed

Affiliation: Laboratoire TIMC-IMAG, UMR 5525 CNRS - University of Grenoble, Grenoble, France.

Show MeSH
Related in: MedlinePlus