Inhibition of cardiac leptin expression after infarction reduces subsequent dysfunction.
Bottom Line: Our results show that (1) cardiac leptin level peaks 7 days after reperfused MI; (2) intramyocardial injection of leptin-AS ODN reduces early IL-1β and IL-6 overexpression and markedly protects contractile function.In conclusion, our findings demonstrate that cardiac leptin expression after MI could contribute to the evolution towards heart failure through autocrine and/or paracrine actions.The detrimental effect of leptin could be mediated by pro-inflammatory cytokines such as IL-1β and IL-6.
Affiliation: Laboratoire TIMC-IMAG, UMR 5525 CNRS - University of Grenoble, Grenoble, France.Show MeSH
Related in: MedlinePlus
Mentions: Myocardial leptin level, measured by cytokine array, progressively increased from day 3 after MI to reach a maximum (+380% versus non-operated) at day 7, before returning to non-operated baseline level at day 10 (Fig. 1).
Affiliation: Laboratoire TIMC-IMAG, UMR 5525 CNRS - University of Grenoble, Grenoble, France.