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Inhibition of cardiac leptin expression after infarction reduces subsequent dysfunction.

Moro C, Grauzam S, Ormezzano O, Toufektsian MC, Tanguy S, Calabrese P, Coll JL, Bak I, Juhasz B, Tosaki A, de Leiris J, Boucher F - J. Cell. Mol. Med. (2011)

Bottom Line: Our results show that (1) cardiac leptin level peaks 7 days after reperfused MI; (2) intramyocardial injection of leptin-AS ODN reduces early IL-1β and IL-6 overexpression and markedly protects contractile function.In conclusion, our findings demonstrate that cardiac leptin expression after MI could contribute to the evolution towards heart failure through autocrine and/or paracrine actions.The detrimental effect of leptin could be mediated by pro-inflammatory cytokines such as IL-1β and IL-6.

View Article: PubMed Central - PubMed

Affiliation: Laboratoire TIMC-IMAG, UMR 5525 CNRS - University of Grenoble, Grenoble, France.

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Related in: MedlinePlus

Evolution of cardiac leptin level during the first 10 days following reperfused MI. Chemiarray™: Blot intensities are expressed as a percentage of positive specific internal controls. n = 3 hearts per point.
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fig01: Evolution of cardiac leptin level during the first 10 days following reperfused MI. Chemiarray™: Blot intensities are expressed as a percentage of positive specific internal controls. n = 3 hearts per point.

Mentions: Myocardial leptin level, measured by cytokine array, progressively increased from day 3 after MI to reach a maximum (+380% versus non-operated) at day 7, before returning to non-operated baseline level at day 10 (Fig. 1).


Inhibition of cardiac leptin expression after infarction reduces subsequent dysfunction.

Moro C, Grauzam S, Ormezzano O, Toufektsian MC, Tanguy S, Calabrese P, Coll JL, Bak I, Juhasz B, Tosaki A, de Leiris J, Boucher F - J. Cell. Mol. Med. (2011)

Evolution of cardiac leptin level during the first 10 days following reperfused MI. Chemiarray™: Blot intensities are expressed as a percentage of positive specific internal controls. n = 3 hearts per point.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4373359&req=5

fig01: Evolution of cardiac leptin level during the first 10 days following reperfused MI. Chemiarray™: Blot intensities are expressed as a percentage of positive specific internal controls. n = 3 hearts per point.
Mentions: Myocardial leptin level, measured by cytokine array, progressively increased from day 3 after MI to reach a maximum (+380% versus non-operated) at day 7, before returning to non-operated baseline level at day 10 (Fig. 1).

Bottom Line: Our results show that (1) cardiac leptin level peaks 7 days after reperfused MI; (2) intramyocardial injection of leptin-AS ODN reduces early IL-1β and IL-6 overexpression and markedly protects contractile function.In conclusion, our findings demonstrate that cardiac leptin expression after MI could contribute to the evolution towards heart failure through autocrine and/or paracrine actions.The detrimental effect of leptin could be mediated by pro-inflammatory cytokines such as IL-1β and IL-6.

View Article: PubMed Central - PubMed

Affiliation: Laboratoire TIMC-IMAG, UMR 5525 CNRS - University of Grenoble, Grenoble, France.

Show MeSH
Related in: MedlinePlus