MicroRNAs and glioblastoma: roles in core signalling pathways and potential clinical implications.
Bottom Line: MicroRNAs (miRNAs) are endogenously expressed small non-coding RNAs that act as post-transcriptional regulators of gene expression.Dysregulation of these molecules has been indicated in the development of many cancers.It was repeatedly found that miRNAs are involved in important signalling pathways, which play roles in crucial cellular processes, such as proliferation, apoptosis, cell cycle regulation, invasion, angiogenesis and stem cell behaviour.
Affiliation: Masaryk Memorial Cancer Institute, Department of Comprehensive Cancer Care, Brno, Czech Republic.Show MeSH
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Mentions: Finally, miR-221 and miR-222 were revealed using bioinformatics analysis as potential regulators of many target genes involved in AKT signalling pathway. Up-regulation of miR-221/222 resulted in remarkable increase of p-Akt and significant changes in expression of Akt-related genes in glioma cells. Consequently, miR-221/222 overexpression increased glioma cell proliferation and invasion in vitro and induced glioma growth in a subcutaneous mouse model. These results suggest that miR-221/222 enhance glioma malignant phenotype via activation of the AKT signalling pathway mediated by regulation of common gene expression (Fig. 1) .
Affiliation: Masaryk Memorial Cancer Institute, Department of Comprehensive Cancer Care, Brno, Czech Republic.