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MicroRNAs and glioblastoma: roles in core signalling pathways and potential clinical implications.

Sana J, Hajduch M, Michalek J, Vyzula R, Slaby O - J. Cell. Mol. Med. (2011)

Bottom Line: MicroRNAs (miRNAs) are endogenously expressed small non-coding RNAs that act as post-transcriptional regulators of gene expression.Dysregulation of these molecules has been indicated in the development of many cancers.It was repeatedly found that miRNAs are involved in important signalling pathways, which play roles in crucial cellular processes, such as proliferation, apoptosis, cell cycle regulation, invasion, angiogenesis and stem cell behaviour.

View Article: PubMed Central - PubMed

Affiliation: Masaryk Memorial Cancer Institute, Department of Comprehensive Cancer Care, Brno, Czech Republic.

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Related in: MedlinePlus

MiRNAs involved in EGFR and PI3K/AKT signalling pathways. EGFR: epidermal growth factor receptor; AKT: serine/threonine protein kinase Akt; PTEN: phosphatase and tensin homologue; Bmi-1: polycomb ring finger oncogene; Raf: raf kinase, effector of Ras; IRS1/2: insulin receptor substrate 1/2; PI3K: Phosphotidylinositol 3 kinase; MMP9/2: matrix metallopeptidase 9/2; p27: cyclin-dependent kinase inhibitor 1B (p27, Kip1); p21: cyclin-dependent kinase inhibitor 1A (p21, Cip1); Bcl-2: B-cell CLL/lymphoma 2; Grb2: growth factor receptor-bound protein 2; SOS: son of sevenless homologue 1; MEK: mitogen-activated protein kinase kinase 1; ERK: extracellular signal-regulated kinase. Dashed lines indicated indirect regulation, solid lines indicate direct regulation.
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fig01: MiRNAs involved in EGFR and PI3K/AKT signalling pathways. EGFR: epidermal growth factor receptor; AKT: serine/threonine protein kinase Akt; PTEN: phosphatase and tensin homologue; Bmi-1: polycomb ring finger oncogene; Raf: raf kinase, effector of Ras; IRS1/2: insulin receptor substrate 1/2; PI3K: Phosphotidylinositol 3 kinase; MMP9/2: matrix metallopeptidase 9/2; p27: cyclin-dependent kinase inhibitor 1B (p27, Kip1); p21: cyclin-dependent kinase inhibitor 1A (p21, Cip1); Bcl-2: B-cell CLL/lymphoma 2; Grb2: growth factor receptor-bound protein 2; SOS: son of sevenless homologue 1; MEK: mitogen-activated protein kinase kinase 1; ERK: extracellular signal-regulated kinase. Dashed lines indicated indirect regulation, solid lines indicate direct regulation.

Mentions: Finally, miR-221 and miR-222 were revealed using bioinformatics analysis as potential regulators of many target genes involved in AKT signalling pathway. Up-regulation of miR-221/222 resulted in remarkable increase of p-Akt and significant changes in expression of Akt-related genes in glioma cells. Consequently, miR-221/222 overexpression increased glioma cell proliferation and invasion in vitro and induced glioma growth in a subcutaneous mouse model. These results suggest that miR-221/222 enhance glioma malignant phenotype via activation of the AKT signalling pathway mediated by regulation of common gene expression (Fig. 1) [20].


MicroRNAs and glioblastoma: roles in core signalling pathways and potential clinical implications.

Sana J, Hajduch M, Michalek J, Vyzula R, Slaby O - J. Cell. Mol. Med. (2011)

MiRNAs involved in EGFR and PI3K/AKT signalling pathways. EGFR: epidermal growth factor receptor; AKT: serine/threonine protein kinase Akt; PTEN: phosphatase and tensin homologue; Bmi-1: polycomb ring finger oncogene; Raf: raf kinase, effector of Ras; IRS1/2: insulin receptor substrate 1/2; PI3K: Phosphotidylinositol 3 kinase; MMP9/2: matrix metallopeptidase 9/2; p27: cyclin-dependent kinase inhibitor 1B (p27, Kip1); p21: cyclin-dependent kinase inhibitor 1A (p21, Cip1); Bcl-2: B-cell CLL/lymphoma 2; Grb2: growth factor receptor-bound protein 2; SOS: son of sevenless homologue 1; MEK: mitogen-activated protein kinase kinase 1; ERK: extracellular signal-regulated kinase. Dashed lines indicated indirect regulation, solid lines indicate direct regulation.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4373357&req=5

fig01: MiRNAs involved in EGFR and PI3K/AKT signalling pathways. EGFR: epidermal growth factor receptor; AKT: serine/threonine protein kinase Akt; PTEN: phosphatase and tensin homologue; Bmi-1: polycomb ring finger oncogene; Raf: raf kinase, effector of Ras; IRS1/2: insulin receptor substrate 1/2; PI3K: Phosphotidylinositol 3 kinase; MMP9/2: matrix metallopeptidase 9/2; p27: cyclin-dependent kinase inhibitor 1B (p27, Kip1); p21: cyclin-dependent kinase inhibitor 1A (p21, Cip1); Bcl-2: B-cell CLL/lymphoma 2; Grb2: growth factor receptor-bound protein 2; SOS: son of sevenless homologue 1; MEK: mitogen-activated protein kinase kinase 1; ERK: extracellular signal-regulated kinase. Dashed lines indicated indirect regulation, solid lines indicate direct regulation.
Mentions: Finally, miR-221 and miR-222 were revealed using bioinformatics analysis as potential regulators of many target genes involved in AKT signalling pathway. Up-regulation of miR-221/222 resulted in remarkable increase of p-Akt and significant changes in expression of Akt-related genes in glioma cells. Consequently, miR-221/222 overexpression increased glioma cell proliferation and invasion in vitro and induced glioma growth in a subcutaneous mouse model. These results suggest that miR-221/222 enhance glioma malignant phenotype via activation of the AKT signalling pathway mediated by regulation of common gene expression (Fig. 1) [20].

Bottom Line: MicroRNAs (miRNAs) are endogenously expressed small non-coding RNAs that act as post-transcriptional regulators of gene expression.Dysregulation of these molecules has been indicated in the development of many cancers.It was repeatedly found that miRNAs are involved in important signalling pathways, which play roles in crucial cellular processes, such as proliferation, apoptosis, cell cycle regulation, invasion, angiogenesis and stem cell behaviour.

View Article: PubMed Central - PubMed

Affiliation: Masaryk Memorial Cancer Institute, Department of Comprehensive Cancer Care, Brno, Czech Republic.

Show MeSH
Related in: MedlinePlus