Role of aquaporin 5 in antigen-induced airway inflammation and mucous hyperproduction in mice.
Bottom Line: The present study firstly found the overexpression of AQP5 in the airway epithelium and submucosal glands of asthmatics.Furthermore, we aimed at evaluating the role of AQP5 in airway inflammation and mucous hyperproductions during chronic allergic responses to house dust mite (HDM).Thus, our results implicate involvement of AQP5 in the development of airway inflammation and mucous hyperproduction during chronic asthma.
Affiliation: Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.Show MeSH
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Mentions: BAL levels of IL-4 (Fig. 3A) and IL-10 (Fig. 3B) in animals challenged with HDM were significantly increased as compared with those with PBS (P < 0.05 and 0.01, respectively). AQP5 KO mice had significantly lower levels of IL-4 and IL-10 than WT mice after chronic exposure to HDM (P < 0.05). BAL levels of IL-2 (Fig. 3C) and IFN-γ (Fig. 3D) in AQP5 KO mice were significantly higher than those in WT mice (P < 0.05), whereas levels in both AQP5 KO and WT mice challenged with HDM were significantly lower than those with PBS (P < 0.01). There was no significant difference between WT and AQP5 KO after the challenge with PBS.
Affiliation: Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.