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Role of aquaporin 5 in antigen-induced airway inflammation and mucous hyperproduction in mice.

Shen Y, Wang Y, Chen Z, Wang D, Wang X, Jin M, Bai C - J. Cell. Mol. Med. (2010)

Bottom Line: The aquaporin (AQP)-5 may be involved in the process due to its contribution to the volume of liquid secreted from the airways.The present study firstly found the overexpression of AQP5 in the airway epithelium and submucosal glands of asthmatics.Furthermore, we aimed at evaluating the role of AQP5 in airway inflammation and mucous hyperproductions during chronic allergic responses to house dust mite (HDM).

View Article: PubMed Central - PubMed

Affiliation: Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.

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Related in: MedlinePlus

Levels of IL-4 (A), IL-10 (B), IL-2 (C) and IFN-γ (D) in BAL fluid harvested from WT and AQP5 KO mice (n= 8/group) after intranasal challenges with HDM, once a day, 5 days a week for 5 weeks; ‘*’ and ‘**’ stand for the P-values less than 0.05 and 0.01, respectively, as compared with WT and AQP5 KO mice challenged with PBS. ‘+’ stands for the P-values less than 0.05, as compared with WT mice challenged with HDM.
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fig03: Levels of IL-4 (A), IL-10 (B), IL-2 (C) and IFN-γ (D) in BAL fluid harvested from WT and AQP5 KO mice (n= 8/group) after intranasal challenges with HDM, once a day, 5 days a week for 5 weeks; ‘*’ and ‘**’ stand for the P-values less than 0.05 and 0.01, respectively, as compared with WT and AQP5 KO mice challenged with PBS. ‘+’ stands for the P-values less than 0.05, as compared with WT mice challenged with HDM.

Mentions: BAL levels of IL-4 (Fig. 3A) and IL-10 (Fig. 3B) in animals challenged with HDM were significantly increased as compared with those with PBS (P < 0.05 and 0.01, respectively). AQP5 KO mice had significantly lower levels of IL-4 and IL-10 than WT mice after chronic exposure to HDM (P < 0.05). BAL levels of IL-2 (Fig. 3C) and IFN-γ (Fig. 3D) in AQP5 KO mice were significantly higher than those in WT mice (P < 0.05), whereas levels in both AQP5 KO and WT mice challenged with HDM were significantly lower than those with PBS (P < 0.01). There was no significant difference between WT and AQP5 KO after the challenge with PBS.


Role of aquaporin 5 in antigen-induced airway inflammation and mucous hyperproduction in mice.

Shen Y, Wang Y, Chen Z, Wang D, Wang X, Jin M, Bai C - J. Cell. Mol. Med. (2010)

Levels of IL-4 (A), IL-10 (B), IL-2 (C) and IFN-γ (D) in BAL fluid harvested from WT and AQP5 KO mice (n= 8/group) after intranasal challenges with HDM, once a day, 5 days a week for 5 weeks; ‘*’ and ‘**’ stand for the P-values less than 0.05 and 0.01, respectively, as compared with WT and AQP5 KO mice challenged with PBS. ‘+’ stands for the P-values less than 0.05, as compared with WT mice challenged with HDM.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4373335&req=5

fig03: Levels of IL-4 (A), IL-10 (B), IL-2 (C) and IFN-γ (D) in BAL fluid harvested from WT and AQP5 KO mice (n= 8/group) after intranasal challenges with HDM, once a day, 5 days a week for 5 weeks; ‘*’ and ‘**’ stand for the P-values less than 0.05 and 0.01, respectively, as compared with WT and AQP5 KO mice challenged with PBS. ‘+’ stands for the P-values less than 0.05, as compared with WT mice challenged with HDM.
Mentions: BAL levels of IL-4 (Fig. 3A) and IL-10 (Fig. 3B) in animals challenged with HDM were significantly increased as compared with those with PBS (P < 0.05 and 0.01, respectively). AQP5 KO mice had significantly lower levels of IL-4 and IL-10 than WT mice after chronic exposure to HDM (P < 0.05). BAL levels of IL-2 (Fig. 3C) and IFN-γ (Fig. 3D) in AQP5 KO mice were significantly higher than those in WT mice (P < 0.05), whereas levels in both AQP5 KO and WT mice challenged with HDM were significantly lower than those with PBS (P < 0.01). There was no significant difference between WT and AQP5 KO after the challenge with PBS.

Bottom Line: The aquaporin (AQP)-5 may be involved in the process due to its contribution to the volume of liquid secreted from the airways.The present study firstly found the overexpression of AQP5 in the airway epithelium and submucosal glands of asthmatics.Furthermore, we aimed at evaluating the role of AQP5 in airway inflammation and mucous hyperproductions during chronic allergic responses to house dust mite (HDM).

View Article: PubMed Central - PubMed

Affiliation: Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.

Show MeSH
Related in: MedlinePlus