Bone regeneration: stem cell therapies and clinical studies in orthopaedics and traumatology.
Bottom Line: Regenerative medicine seeks to repair or replace damaged tissues or organs, with the goal to fully restore structure and function without the formation of scar tissue.Cell based therapies are promising new therapeutic approaches in regenerative medicine.Both translational and clinical research will move the boundaries in the field of regenerative medicine, and a coordinated effort will provide the clinical breakthroughs, particularly in the many applications of bone engineering.
Affiliation: Orthopaedic Surgery Service, Hospital Universitario La Paz, Autónoma University of Madrid, Madrid, Spain. email@example.comShow MeSH
Related in: MedlinePlus
Mentions: Local bone defects, whatever the cause of the defects, are at this point the main indications for cell/combination therapy in adults. Osteoporosis, a systemic metabolic bone disease, may be a target in the future due to the risk for associated fractures and related local problems. The main orthopaedic problems in adults are non-union or delayed consolidation following fracture (as an example, Fig. 5), osteotomy, arthrodesis or limb lengthening; bone defects subsequent to trauma, infection, prosthesis loosening or tumour resection and finally, bone necrosis (particularly, avascular necrosis [AVN] of the femoral head, as shown in Fig. 6).
Affiliation: Orthopaedic Surgery Service, Hospital Universitario La Paz, Autónoma University of Madrid, Madrid, Spain. firstname.lastname@example.org