Bone regeneration: stem cell therapies and clinical studies in orthopaedics and traumatology.
Bottom Line: Regenerative medicine seeks to repair or replace damaged tissues or organs, with the goal to fully restore structure and function without the formation of scar tissue.Cell based therapies are promising new therapeutic approaches in regenerative medicine.Both translational and clinical research will move the boundaries in the field of regenerative medicine, and a coordinated effort will provide the clinical breakthroughs, particularly in the many applications of bone engineering.
Affiliation: Orthopaedic Surgery Service, Hospital Universitario La Paz, Autónoma University of Madrid, Madrid, Spain. email@example.comShow MeSH
Related in: MedlinePlus
Mentions: Tissue engineering combines MSCs, synthetic scaffolds and molecular signals (growth or differentiating factors) in order to form hybrid constructs. In a classical approach, bone tissue engineering consists of harvesting BM from a patient, culturing those cells in vitro to a sufficient number (amplification) and then seeding onto a suitable scaffold prior to implantation into the same patient for differentiation and/or tissue regeneration [7, 8]. The sketch in Figure 1 illustrates the initial concept of bone tissue engineering.
Affiliation: Orthopaedic Surgery Service, Hospital Universitario La Paz, Autónoma University of Madrid, Madrid, Spain. firstname.lastname@example.org