Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia.
Bottom Line: The oxygen partial pressure (pO(2)), which is a key component of the physiological state of an organ, results from the balance between oxygen delivery and its consumption.More importantly we emphasize the discrepancy between in vivo and in vitro tissue and cells oxygen status which can have detrimental effects on experimental outcome.It is important to realize that most of the experiments performed in so-called normoxia might be dangerously misleading.
Affiliation: Centre de Biophysique Moléculaire, CNRS UPR, Orléans, France.Show MeSH
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Mentions: PET is an in vivo tomographic imaging technique. It is based on the detection of anti-parallel 511 keV photons emitted during the annihilation of positrons with electrons. PET radiotracers are physiologically and pharmacologically relevant compounds labelled with short-lived positron-emitting radionuclides. After internalization by injection or inhalation, the tracer reaches the target and the quantity is then detected with a PET scanner, with a ring-shaped array of photoelectric crystals  (Fig. 2).
Affiliation: Centre de Biophysique Moléculaire, CNRS UPR, Orléans, France.