The potential utility of telomere-related markers for cancer diagnosis.
Bottom Line: Telomeres are nucleoprotein complexes comprising the hexanucleotide DNA repeat sequence, TTAGGG and numerous telomere-associated proteins, including the six member Shelterin complex.Future directions focusing on the direct detection of dysfunctional telomeres are explored.New markers for telomere dysfunction may eventually prove clinically useful.
Affiliation: Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA. firstname.lastname@example.orgShow MeSH
Related in: MedlinePlus
Mentions: Although previous investigations have assessed telomere shortening in cancer cells, these length measurements have been considered a proxy for telomere dysfunction. The schematic in Figure 1 highlights the finding that the majority of tumours have telomere length alterations, either shortening or lengthening, that can eventually lead to telomere dysfunction. Although telomere length changes per se are unlikely to be useful diagnostic biomarkers, identification of the fundamental underlying molecular changes that cause telomere destabilization may unmask new markers that can aid in diagnosis of cancer.
Affiliation: Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA. email@example.com